Common brain disorders are associated with heritable patterns of apparent aging of the brain

Karolinska Schizophrenia Project (KaSP)

doi:10.1038/s41593-019-0471-7

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Karolinska Schizophrenia Project (KaSP)

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Original language	English (US)
Pages (from-to)	1617-1623
Number of pages	7
Journal	Nature neuroscience
Volume	22
Issue number	10
DOIs	https://doi.org/10.1038/s41593-019-0471-7
State	Published - Oct 1 2019

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/s41593-019-0471-7

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title = "Common brain disorders are associated with heritable patterns of apparent aging of the brain",

abstract = "Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.",

author = "{Karolinska Schizophrenia Project (KaSP)} and Tobias Kaufmann and {van der Meer}, Dennis and Doan, {Nhat Trung} and Emanuel Schwarz and Lund, {Martina J.} and Ingrid Agartz and Dag Aln{\ae}s and Barch, {Deanna M.} and Ramona Baur-Streubel and Alessandro Bertolino and Francesco Bettella and Beyer, {Mona K.} and Erlend B{\o}en and Stefan Borgwardt and Brandt, {Christine L.} and Jan Buitelaar and Celius, {Elisabeth G.} and Simon Cervenka and Annette Conzelmann and Aldo C{\'o}rdova-Palomera and Dale, {Anders M.} and {de Quervain}, {Dominique J.F.} and Carlo, {Pasquale Di} and Srdjan Djurovic and D{\o}rum, {Erlend S.} and Sarah Eisenacher and Torbj{\o}rn Elvs{\aa}shagen and Thomas Espeseth and Helena Fatouros-Bergman and Lena Flyckt and Barbara Franke and Oleksandr Frei and Beathe Haatveit and H{\aa}berg, {Asta K.} and Harbo, {Hanne F.} and Hartman, {Catharina A.} and Dirk Heslenfeld and Hoekstra, {Pieter J.} and H{\o}gest{\o}l, {Einar A.} and Jernigan, {Terry L.} and Rune Jonassen and J{\"o}nsson, {Erik G.} and Lars Farde and Lena Flyckt and G{\"o}ran Engberg and Sophie Erhardt and Helena Fatouros-Bergman and Simon Cervenka and Lilly Schwieler and Lei Wang",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2019",

month = oct,

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doi = "10.1038/s41593-019-0471-7",

language = "English (US)",

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AU - Karolinska Schizophrenia Project (KaSP)

AU - Kaufmann, Tobias

AU - van der Meer, Dennis

AU - Doan, Nhat Trung

AU - Schwarz, Emanuel

AU - Lund, Martina J.

AU - Agartz, Ingrid

AU - Alnæs, Dag

AU - Barch, Deanna M.

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bettella, Francesco

AU - Beyer, Mona K.

AU - Bøen, Erlend

AU - Borgwardt, Stefan

AU - Brandt, Christine L.

AU - Buitelaar, Jan

AU - Celius, Elisabeth G.

AU - Cervenka, Simon

AU - Conzelmann, Annette

AU - Córdova-Palomera, Aldo

AU - Dale, Anders M.

AU - de Quervain, Dominique J.F.

AU - Carlo, Pasquale Di

AU - Djurovic, Srdjan

AU - Dørum, Erlend S.

AU - Eisenacher, Sarah

AU - Elvsåshagen, Torbjørn

AU - Espeseth, Thomas

AU - Fatouros-Bergman, Helena

AU - Flyckt, Lena

AU - Franke, Barbara

AU - Frei, Oleksandr

AU - Haatveit, Beathe

AU - Håberg, Asta K.

AU - Harbo, Hanne F.

AU - Hartman, Catharina A.

AU - Heslenfeld, Dirk

AU - Hoekstra, Pieter J.

AU - Høgestøl, Einar A.

AU - Jernigan, Terry L.

AU - Jonassen, Rune

AU - Jönsson, Erik G.

AU - Farde, Lars

AU - Flyckt, Lena

AU - Engberg, Göran

AU - Erhardt, Sophie

AU - Fatouros-Bergman, Helena

AU - Cervenka, Simon

AU - Schwieler, Lilly

AU - Wang, Lei

PY - 2019/10/1

Y1 - 2019/10/1

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JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 10

ER -

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Abstract

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