Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R. Gao, P. Penzes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may provi de essential insight into the etiology of these disorders and may uncover novel targets for future drug discovery. Here, we review key genetic, physiological, neuropathological, functional, and pathway studies that suggest alterations to excitatory/inhibitory circuits are keys to ASD and SCZ pathogenesis.

Original languageEnglish (US)
Pages (from-to)146-167
Number of pages22
JournalCurrent Molecular Medicine
Volume15
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Autism
  • Dendritic spine
  • E/I imbalance
  • GABAergic interneuron
  • Glutamatergic
  • NMDAR
  • Schizophrenia
  • mTOR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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