TY - JOUR
T1 - Community-acquired pneumonia
T2 - Pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infections
AU - Wunderink, Richard G.
AU - Waterer, Grant W.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2004/12
Y1 - 2004/12
N2 - The present understanding of the pathophysiology of community-acquire pneumonia (CAP) explains the mechanism for many specific manifestations, but does not address adequately why only some patients experience complications. Recent advances in understanding the genetics of complex illnesses offer hope for a more complete insight into the pathogenesis of CAP. This article reviews genetic variation in the molecules involved in the known pathogenic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response, and organ dysfunction.
AB - The present understanding of the pathophysiology of community-acquire pneumonia (CAP) explains the mechanism for many specific manifestations, but does not address adequately why only some patients experience complications. Recent advances in understanding the genetics of complex illnesses offer hope for a more complete insight into the pathogenesis of CAP. This article reviews genetic variation in the molecules involved in the known pathogenic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response, and organ dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=8844240047&partnerID=8YFLogxK
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U2 - 10.1016/j.idc.2004.07.004
DO - 10.1016/j.idc.2004.07.004
M3 - Review article
C2 - 15555822
AN - SCOPUS:8844240047
VL - 18
SP - 743
EP - 759
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
SN - 0891-5520
IS - 4
ER -