Abstract
Purpose of reviewRespiratory viruses are common in solid organ transplant (SOT) recipients and recognized as a significant cause of mortality and morbidity. This review examines the literature on influenza and noninfluenza viruses in the SOT recipient.Recent findingsAdvances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, yet respiratory viruses continue to be a common cause of disease in this population. Influenza viruses have received top priority regarding prevention and treatment, whereas advances in molecular diagnostic tests detecting an array of other respiratory viruses have expanded our knowledge about the epidemiology and impact of these viruses in both the general population and SOT patients. Effective treatment and prevention for noninfluenza respiratory viruses are only emerging.SummaryRespiratory viruses can contribute to a wide array of symptoms in SOT, particularly in lung transplant recipients. The clinical manifestations, diagnosis, and treatment options for influenza and noninfluenza viruses in SOT patients are reviewed. PCR and related molecular techniques represent the most sensitive diagnostic modalities for detection of respiratory viruses. Early therapy is associated with improved outcomes. Newer classes of antivirals and antibodies are under continuous development for many of these community acquired respiratory viruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 483-489 |
| Number of pages | 7 |
| Journal | Current opinion in organ transplantation |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2019 |
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Keywords
- antivirals
- epidemiology
- human metapneumovirus
- human orthopneumovirus
- human parainfluenza virus
- human respiratory syncytial virus
- influenza
- multiplex
- parainfluenza virus
- respiratory tract viruses
- solid organ transplantation
- vaccination
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation
Cite this
}
Community-acquired respiratory viruses in solid organ transplant. / Nam, Hannah H.; Ison, Michael G.
In: Current opinion in organ transplantation, Vol. 24, No. 4, 01.08.2019, p. 483-489.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Community-acquired respiratory viruses in solid organ transplant
AU - Nam, Hannah H.
AU - Ison, Michael G
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Purpose of reviewRespiratory viruses are common in solid organ transplant (SOT) recipients and recognized as a significant cause of mortality and morbidity. This review examines the literature on influenza and noninfluenza viruses in the SOT recipient.Recent findingsAdvances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, yet respiratory viruses continue to be a common cause of disease in this population. Influenza viruses have received top priority regarding prevention and treatment, whereas advances in molecular diagnostic tests detecting an array of other respiratory viruses have expanded our knowledge about the epidemiology and impact of these viruses in both the general population and SOT patients. Effective treatment and prevention for noninfluenza respiratory viruses are only emerging.SummaryRespiratory viruses can contribute to a wide array of symptoms in SOT, particularly in lung transplant recipients. The clinical manifestations, diagnosis, and treatment options for influenza and noninfluenza viruses in SOT patients are reviewed. PCR and related molecular techniques represent the most sensitive diagnostic modalities for detection of respiratory viruses. Early therapy is associated with improved outcomes. Newer classes of antivirals and antibodies are under continuous development for many of these community acquired respiratory viruses.
AB - Purpose of reviewRespiratory viruses are common in solid organ transplant (SOT) recipients and recognized as a significant cause of mortality and morbidity. This review examines the literature on influenza and noninfluenza viruses in the SOT recipient.Recent findingsAdvances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, yet respiratory viruses continue to be a common cause of disease in this population. Influenza viruses have received top priority regarding prevention and treatment, whereas advances in molecular diagnostic tests detecting an array of other respiratory viruses have expanded our knowledge about the epidemiology and impact of these viruses in both the general population and SOT patients. Effective treatment and prevention for noninfluenza respiratory viruses are only emerging.SummaryRespiratory viruses can contribute to a wide array of symptoms in SOT, particularly in lung transplant recipients. The clinical manifestations, diagnosis, and treatment options for influenza and noninfluenza viruses in SOT patients are reviewed. PCR and related molecular techniques represent the most sensitive diagnostic modalities for detection of respiratory viruses. Early therapy is associated with improved outcomes. Newer classes of antivirals and antibodies are under continuous development for many of these community acquired respiratory viruses.
KW - antivirals
KW - epidemiology
KW - human metapneumovirus
KW - human orthopneumovirus
KW - human parainfluenza virus
KW - human respiratory syncytial virus
KW - influenza
KW - multiplex
KW - parainfluenza virus
KW - respiratory tract viruses
KW - solid organ transplantation
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85069619949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069619949&partnerID=8YFLogxK
U2 - 10.1097/MOT.0000000000000663
DO - 10.1097/MOT.0000000000000663
M3 - Review article
C2 - 31145157
AN - SCOPUS:85069619949
VL - 24
SP - 483
EP - 489
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
SN - 1087-2418
IS - 4
ER -