Comorbidities and the impact of atopic dermatitis

Jonathan I. Silverberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations


Objective: Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial patient and population burdens. A number of comorbid health problems occur in patients with AD, aside from the cutaneous signs and symptoms. This review summarizes recent developments in the burden and comorbidities of AD. Data Sources: Literature review. Study Selections: Nonsystematic. Results: Different aspects of AD, such as chronic pruritus, psychosocial distress, and inflammation, can lead to anxiety, depression, or suicidality. Atopic dermatitis is associated with and may predispose to higher risk of other atopic disorders, including asthma, hay fever, food allergy, and eosinophilic esophagitis. Persons with AD appear to be at higher risk for infectious and cardiovascular risk. Conclusion: Atopic dermatitis is associated with substantial burden and comorbidities. Identifying AD comorbidities is essential for proper disease management and improving overall patient outcomes.

Original languageEnglish (US)
Pages (from-to)144-151
Number of pages8
JournalAnnals of Allergy, Asthma and Immunology
Issue number2
StatePublished - Aug 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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