Comparative analyses of a family of potential self-replicators: The subtle interplay between molecular structure and the efficacy of self-replication

Russell J. Pearson, Eleftherios Kassianidis, Alexandra M.Z. Slawin, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and repli cation efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes.

Original languageEnglish (US)
Pages (from-to)6829-6840
Number of pages12
JournalChemistry - A European Journal
Volume12
Issue number26
DOIs
StatePublished - Sep 6 2006

Keywords

  • Kinetics
  • Molecular recognition
  • Recognition-mediated reactions
  • Self-replication
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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