TY - JOUR
T1 - Comparative analysis of SOX3 protein orthologs
T2 - Expansion of homopolymeric amino acid tracts during vertebrate evolution
AU - Mojsin, Marija
AU - Kovacevic-Grujicic, Natasa
AU - Krstic, Aleksandar
AU - Popovic, Jelena
AU - Milivojevic, Milena
AU - Stevanovic, Milena
PY - 2010/8
Y1 - 2010/8
N2 - To understand more fully the structure and evolution of the SOX3 protein, we comparatively analyzed its orthologs in vertebrates. Since complex disorders are associated with human SOX3 polyalanine expansions, our investigation focused on both compositional and evolutionary analysis of various homopolymeric amino acid tracts observed in SOX3 orthologs. Our analysis revealed that the observed homopolymeric alanine, glycine, and proline tracts are mammal-specific, except for one polyglycine tract present in birds. Since it is likely that the SOX3 protein acquired additional roles in brain development in Eutheria, we might speculate that development of novel brain functions during the course of evolution was affected, at least in part, by such structural-functional changes in the SOX3 protein.
AB - To understand more fully the structure and evolution of the SOX3 protein, we comparatively analyzed its orthologs in vertebrates. Since complex disorders are associated with human SOX3 polyalanine expansions, our investigation focused on both compositional and evolutionary analysis of various homopolymeric amino acid tracts observed in SOX3 orthologs. Our analysis revealed that the observed homopolymeric alanine, glycine, and proline tracts are mammal-specific, except for one polyglycine tract present in birds. Since it is likely that the SOX3 protein acquired additional roles in brain development in Eutheria, we might speculate that development of novel brain functions during the course of evolution was affected, at least in part, by such structural-functional changes in the SOX3 protein.
KW - Comparative protein analysis
KW - Homopolymeric amino acid tract
KW - Polyalanine expansion
KW - SOX3 protein
UR - http://www.scopus.com/inward/record.url?scp=77956191342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956191342&partnerID=8YFLogxK
U2 - 10.1007/s10528-010-9343-2
DO - 10.1007/s10528-010-9343-2
M3 - Article
C2 - 20495863
AN - SCOPUS:77956191342
SN - 0006-2928
VL - 48
SP - 612
EP - 623
JO - Biochemical Genetics
JF - Biochemical Genetics
IS - 7-8
ER -