Comparative distribution, excretion, and metabolism of 14C‐labeled quaternary ammonium compounds of promazine, chlorpromazine, and triflupromazine

C. L. Huang*, J. Z. Yeh, I. A. Muni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The tissue distribution and biotransformation patterns of the quaternary methiodides of promazine, chlorpromazine, and triflupromazine in rats were investigated. After parenteral administration, high concentrations of these compounds were found in the liver, kidneys, and intestines. The majority of these compounds was metabolized by the liver and excreted in the intestines via the bile duct. In contrast to the corresponding tertiary amine, the majority of these compounds was excreted unchanged; however, a trace of chlorpromazine sulfoxide methiodide was detected in the urine.

Original languageEnglish (US)
Pages (from-to)1114-1118
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume59
Issue number8
DOIs
StatePublished - Jan 1 1970

Keywords

  • Biotransformation, distribution—quaternary phenothiazine compounds
  • IR spectrophotometry—identity
  • Promazine, chlorpromazine, triflupromazine C‐methiodides—synthesis
  • Radiochromatography—analysis
  • Scintillometry—analysis
  • Triflupromazine, chlorpromazine, promazine C‐methiodides—synthesis
  • UV spectrophotometry—identity

ASJC Scopus subject areas

  • Pharmaceutical Science

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