The tissue distribution and biotransformation patterns of the quaternary methiodides of promazine, chlorpromazine, and triflupromazine in rats were investigated. After parenteral administration, high concentrations of these compounds were found in the liver, kidneys, and intestines. The majority of these compounds was metabolized by the liver and excreted in the intestines via the bile duct. In contrast to the corresponding tertiary amine, the majority of these compounds was excreted unchanged; however, a trace of chlorpromazine sulfoxide methiodide was detected in the urine.
- Biotransformation, distribution—quaternary phenothiazine compounds
- IR spectrophotometry—identity
- Promazine, chlorpromazine, triflupromazine C‐methiodides—synthesis
- Triflupromazine, chlorpromazine, promazine C‐methiodides—synthesis
- UV spectrophotometry—identity
ASJC Scopus subject areas
- Pharmaceutical Science