Comparative effectiveness of intravenous vs oral antibiotics for Postdischarge treatment ofacuteosteomyelitis in children

Ron Keren*, Samir S. Shah, Rajendu Srivastava, Shawn Rangel, Michael Bendel-Stenzel, Nada Harik, John Hartley, Michelle Lopez, Luis Seguias, Joel Tieder, Matthew Bryan, Wu Gong, Matt Hall, Russell Localio, Xianqun Luan, Rachel De Berardinis, Allison Parker, Chris Miller, Wendy Hoffner, Suchitra RaoDerek J. Williams, Cynthia D. Cross, Jeffrey Colvin, Susan Wu, Waheeda Samady, Paul Ishimine, Thomas A. Coffelt, Ben Bauer, Mythili Srinivasan, Ilana Waynik, Brett Anderson, Marcos Mestre, Adam Berkwitt, John Kinnison, Tiffany Shea Osburn, Bhanumathy Kumar, David Kotzbauer, George Hescock, Sheilah Snyder, Edward Chu, Sri Narayanan, Bahman Panbehi, Nader Shaikh, Rainer Gedeit, Marc Mazade, Kristen Sheets, Joni Oberlin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


IMPORTANCE: Postdischarge treatment of acute osteomyelitis in children requires weeks of antibiotic therapy, which can be administered orally or intravenously via a peripherally inserted central catheter (PICC). The catheters carry a risk for serious complications, but limited evidence exists on the effectiveness of oral therapy. OBJECTIVE: To compare the effectiveness and adverse outcomes of postdischarge antibiotic therapy administered via the PICC or the oral route. DESIGN, SETTING, AND PARTICIPANTS: We performed a retrospective cohort study comparing PICC and oral therapy for the treatment of acute osteomyelitis. Among children hospitalized from January 1, 2009, through December 31, 2012, at 36 participating children's hospitals, we used discharge codes to identify potentially eligible participants. Results of medical record review confirmed eligibility and defined treatment group allocation and study outcomes.We used within- and across-hospital propensity score-based full matching to adjust for confounding by indication. INTERVENTIONS: Postdischarge administration of antibiotics via the PICC or the oral route. MAIN OUTCOMES AND MEASURES: The primary outcomewas treatment failure. Secondary outcomes included adverse drug reaction, PICC line complication, and a composite of all 3 end points. RESULTS: Among 2060 children and adolescents (hereinafter referred to as children) with osteomyelitis, 1005 received oral antibiotics at discharge, whereas 1055 received PICC-administered antibiotics. The proportion of children treated via the PICC route varied across hospitals from 0 to 100%. In the across-hospital (risk difference, 0.3%[95%CI, -0.1% to 2.5%]) and within-hospital (risk difference, 0.6%[95%CI, -0.2%to 3.0%]) matched analyses, children treated with antibiotics via the oral route (reference group) did not experience more treatment failures than those treated with antibiotics via the PICC route. Rates of adverse drug reaction were low (<4%in both groups) but slightly greater in the PICC group in across-hospital (risk difference, 1.7%[95%CI, 0.1%-3.3%]) and within-hospital (risk difference, 2.1%[95%CI, 0.3%-3.8%]) matched analyses. Among the children in the PICC group, 158 (15.0%) had a PICC complication that required an emergency department visit (n = 96), a rehospitalization (n = 38), or both (n = 24). As a result, the PICC group had a much higher risk of requiring a return visit to the emergency department or for hospitalization for any adverse outcome in across-hospital (risk difference, 14.6%[95%CI, 11.3%-17.9%]) and within-hospital (risk difference, 14.0% [95%CI, 10.5%-17.6%]) matched analyses. CONCLUSIONS AND RELEVANCE: Given the magnitude and seriousness of PICC complications, clinicians should reconsider the practice of treating otherwise healthy children with acute osteomyelitis with prolonged intravenous antibiotics after hospital discharge when an equally effective oral alternative exists.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalJAMA Pediatrics
Issue number2
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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