Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-Aluminum-garnet laser for treatment of diffuse facial erythema

A double-blind randomized controlled trial

Murad Alam*, Nataya Voravutinon, Melanie Warycha, Dennis Whiting, Michael Nodzenski, Simon S Yoo, Dennis P West, Emir Veledar, Emily Poon Samuelson

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies. Objective: We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-Aluminum- garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema. Methods: This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded. Results: Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57% women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9%) and Nd:YAG (2.5%), but varied by treatment type, with PDL reducing facial redness 6.4% more from baseline than Nd:YAG (P =.0199; 95% confidence interval -11.6 to -1.2). Pain varied (P =.0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52% as a result of PDL, and 34% as a result of Nd:YAG (P =.031; 95% confidence interval -34.6 to -1.94). No serious adverse events were observed. Limitations: Lasers settings are not standardized across devices. Conclusion: Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume69
Issue number3
DOIs
StatePublished - Sep 1 2013

Fingerprint

Dye Lasers
Neodymium
Solid-State Lasers
Erythema
Randomized Controlled Trials
Therapeutics
Pain
Lasers
Confidence Intervals
Patient Preference
Cheek
yttrium-aluminum-garnet
Blood Vessels
Reading
Equipment and Supplies
Skin

Keywords

  • comparative effectiveness research
  • dye
  • erythema
  • lasers
  • rosacea

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{da1830b6f1d341b5967e903afec383f8,
title = "Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-Aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial",
abstract = "Background: Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies. Objective: We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-Aluminum- garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema. Methods: This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded. Results: Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57{\%} women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9{\%}) and Nd:YAG (2.5{\%}), but varied by treatment type, with PDL reducing facial redness 6.4{\%} more from baseline than Nd:YAG (P =.0199; 95{\%} confidence interval -11.6 to -1.2). Pain varied (P =.0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52{\%} as a result of PDL, and 34{\%} as a result of Nd:YAG (P =.031; 95{\%} confidence interval -34.6 to -1.94). No serious adverse events were observed. Limitations: Lasers settings are not standardized across devices. Conclusion: Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful.",
keywords = "comparative effectiveness research, dye, erythema, lasers, rosacea",
author = "Murad Alam and Nataya Voravutinon and Melanie Warycha and Dennis Whiting and Michael Nodzenski and Yoo, {Simon S} and West, {Dennis P} and Emir Veledar and Samuelson, {Emily Poon}",
year = "2013",
month = "9",
day = "1",
doi = "10.1016/j.jaad.2013.04.015",
language = "English (US)",
volume = "69",
pages = "438--443",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-Aluminum-garnet laser for treatment of diffuse facial erythema

T2 - A double-blind randomized controlled trial

AU - Alam, Murad

AU - Voravutinon, Nataya

AU - Warycha, Melanie

AU - Whiting, Dennis

AU - Nodzenski, Michael

AU - Yoo, Simon S

AU - West, Dennis P

AU - Veledar, Emir

AU - Samuelson, Emily Poon

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Background: Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies. Objective: We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-Aluminum- garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema. Methods: This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded. Results: Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57% women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9%) and Nd:YAG (2.5%), but varied by treatment type, with PDL reducing facial redness 6.4% more from baseline than Nd:YAG (P =.0199; 95% confidence interval -11.6 to -1.2). Pain varied (P =.0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52% as a result of PDL, and 34% as a result of Nd:YAG (P =.031; 95% confidence interval -34.6 to -1.94). No serious adverse events were observed. Limitations: Lasers settings are not standardized across devices. Conclusion: Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful.

AB - Background: Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies. Objective: We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-Aluminum- garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema. Methods: This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded. Results: Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57% women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9%) and Nd:YAG (2.5%), but varied by treatment type, with PDL reducing facial redness 6.4% more from baseline than Nd:YAG (P =.0199; 95% confidence interval -11.6 to -1.2). Pain varied (P =.0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52% as a result of PDL, and 34% as a result of Nd:YAG (P =.031; 95% confidence interval -34.6 to -1.94). No serious adverse events were observed. Limitations: Lasers settings are not standardized across devices. Conclusion: Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful.

KW - comparative effectiveness research

KW - dye

KW - erythema

KW - lasers

KW - rosacea

UR - http://www.scopus.com/inward/record.url?scp=84882850569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882850569&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2013.04.015

DO - 10.1016/j.jaad.2013.04.015

M3 - Article

VL - 69

SP - 438

EP - 443

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -