Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis

Iain Anderson, Alexei Sorokin, Vinayak Kapatral*, Gary Reznik, Anamitra Bhattacharya, Natalia Mikhailova, Henry Burd, Victor Joukov, Denis Kaznadzey, Theresa Walunas, Mark D'Souza, Niels Larsen, Gordon Pusch, Konstantinos Liolios, Yuri Grechkin, Alla Lapidus, Eugene Goltsman, Lien Chu, Michael Fonstein, S. Dusko EhrlichRoss Overbeek, Nikos Kyrpides, Natalia Ivanova

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp. israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B. subtilis. A model for regulation of the stress responsive sigma factor σB in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalFEMS Microbiology Letters
Volume250
Issue number2
DOIs
StatePublished - Sep 15 2005

Keywords

  • B. subtilis
  • Bacillus cereus group
  • Comparative genomics

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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