TY - JOUR
T1 - Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis
AU - Anderson, Iain
AU - Sorokin, Alexei
AU - Kapatral, Vinayak
AU - Reznik, Gary
AU - Bhattacharya, Anamitra
AU - Mikhailova, Natalia
AU - Burd, Henry
AU - Joukov, Victor
AU - Kaznadzey, Denis
AU - Walunas, Theresa
AU - D'Souza, Mark
AU - Larsen, Niels
AU - Pusch, Gordon
AU - Liolios, Konstantinos
AU - Grechkin, Yuri
AU - Lapidus, Alla
AU - Goltsman, Eugene
AU - Chu, Lien
AU - Fonstein, Michael
AU - Ehrlich, S. Dusko
AU - Overbeek, Ross
AU - Kyrpides, Nikos
AU - Ivanova, Natalia
N1 - Funding Information:
This work was supported in part by DARPA STTR Grant DAAH01-99-C-R208 to Integrated Genomics Inc and by INRA France. We thank Dr. Robert Haselkorn, University of Chicago for critically reading the manuscript.
PY - 2005/9/15
Y1 - 2005/9/15
N2 - Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp. israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B. subtilis. A model for regulation of the stress responsive sigma factor σB in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified.
AB - Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp. israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B. subtilis. A model for regulation of the stress responsive sigma factor σB in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified.
KW - B. subtilis
KW - Bacillus cereus group
KW - Comparative genomics
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U2 - 10.1016/j.femsle.2005.07.008
DO - 10.1016/j.femsle.2005.07.008
M3 - Article
C2 - 16099605
AN - SCOPUS:23944515302
SN - 0378-1097
VL - 250
SP - 175
EP - 184
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2
ER -