Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b

R. Yogev, W. Glogowski, E. Connor

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A total of 42 strains of Haemophilus influenzae type b isolated from pediatric patients were sensitive in vitro to temocillin (90% minimal inhibitory concentration = 0.25 μg/ml). No difference in mean minimal inhibitory concentration between β-lactamase producer (0.25 μg/ml) and nonproducer (0.23 μg/ml) strains was found. Various dosages of ampicillin or temocillin for the treatment of infant rats with ampicillin-resistant H. influenzae bacteremia and meningitis yielded no difference in cure rates. These results suggest that temocillin may not be as effective as other new cephalosporins for the treatment of H. influenzae type b infections.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume23
Issue number1
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b'. Together they form a unique fingerprint.

  • Cite this