Abstract
Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.
Original language | English (US) |
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Pages (from-to) | 243-257.e7 |
Journal | Cancer cell |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - Feb 10 2020 |
Funding
R.G.W.V. declares equity in Boundless Bio, Inc. A.B.H. receives royalties and milestone payments for licensed intellectual property from Celldex Therapeutics, research grant support from Merck, and is a scientific board member for Caris Life Sciences. The other authors declare no competing interests. This work is supported by grants from the National Institutes of Health (NIH): Cancer Center Support grants P30CA16672 and P30CA034196 and Cancer Center Support Grant Supplement 3P30CA016672-41S7 (A.B.H.); R01 CA190121 (R.G.W.V.), R01 CA120813 (A.B.H.); P0 1CA207206 (J.H.R.); an unrestricted grant from Agilent Technologies (R.G.W.V.); and philanthropic support from Mr. Herb Simmons (A.B.H.). E.K. is recipient of an MD-Fellowship by the Boehringer Ingelheim Fonds and is supported by the German Academic Scholarship Foundation . F.S.V. is supported by a postdoctoral fellowship from The Jane Coffin Childs Memorial Fund for Medical Research. F.P.B. is supported by the JAX Scholar program and K99 CA226387 . K.C.J. is the recipient of an American Cancer Society Fellowship (130984-PF-17-141-01-DMC). This work was partially supported (A.K.L., C.M.) by the Intramural Program of the National Cancer Institute , NIH ( Z01-BC006161 ). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. This work is supported by grants from the National Institutes of Health (NIH): Cancer Center Support grants P30CA16672 and P30CA034196 and Cancer Center Support Grant Supplement 3P30CA016672-41S7 (A.B.H.); R01 CA190121 (R.G.W.V.), R01 CA120813 (A.B.H.); P0 1CA207206 (J.H.R.); an unrestricted grant from Agilent Technologies (R.G.W.V.); and philanthropic support from Mr. Herb Simmons (A.B.H.). E.K. is recipient of an MD-Fellowship by the Boehringer Ingelheim Fonds and is supported by the German Academic Scholarship Foundation. F.S.V. is supported by a postdoctoral fellowship from The Jane Coffin Childs Memorial Fund for Medical Research. F.P.B. is supported by the JAX Scholar program and K99 CA226387. K.C.J. is the recipient of an American Cancer Society Fellowship (130984-PF-17-141-01-DMC). This work was partially supported (A.K.L. C.M.) by the Intramural Program of the National Cancer Institute, NIH (Z01-BC006161). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. R.G.W.V. J.M.L. and A.B.H. conceived, supervised, and financially supported the study. C.E.B. P.J.D. J.W.K. J.M.L. R.A.P. J.H.R. and A.R.T. provided canine patient samples. J.W.K. A.D.M. C.R.M. B.F.P. D.R.R. C.M. K.D.W. and A.K.L. provided consensus histopathological classification on canine gliomas. Sample processing, quality control, and sequencing was performed by C.Y.N. and M.B. S.B.A. and R.G.W.V. designed analysis themes. S.B.A. K.C.J. C.E.B. and M.C. collected patient samples and curated metadata. Data analysis was led by S.B.A. in collaboration with K.J.A. K.C.J. F.P.B. E.K. H.K. E.M.-L. and F.S.V. All authors participated in the discussion of the results. S.B.A. and R.G.W.V. wrote the manuscript. All co-authors discussed the results and commented on the manuscript and Supplementary Information. R.G.W.V. declares equity in Boundless Bio, Inc. A.B.H. receives royalties and milestone payments for licensed intellectual property from Celldex Therapeutics, research grant support from Merck, and is a scientific board member for Caris Life Sciences. The other authors declare no competing interests.
Keywords
- adult glioma
- canine glioma
- comparative genomics
- comparative oncology
- computational biology
- life history
- mutagenesis
- pediatric glioma
ASJC Scopus subject areas
- Oncology
- Cancer Research