Comparative study of marginal zone lymphoma involving bone marrow

Sara A. Kent, Daina Variakojis, Lo Ann C. Peterson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Few studies have characterized or compared the pathologic features of bone marrow involvement by extranodal (EMZL), splenic (SMZL), and nodal marginal zone lymphoma (NMZL). We evaluated 45 bone marrow biopsy specimens from 39 patients with marginal zone lymphomas. As previously reported, bone marrow involvement was frequent (100%) in patients with SMZL. We also identified lymphoma involving bone marrow in 11 (44%) of 25 patients with EMZL and 1 of 2 patients with NMZL. The patterns of infiltration were mixed in all groups; however, the extent of involvement was greater in SMZL than in EMZL. In addition, germinal centers were present in bone marrow biopsy specimens involved by lymphoma in 4 patients with SMZL. Intrasinusoidal infiltration was common (10/12 [83%]) and prominent in patients with bone marrow involvement by SMZL, but was not invariably present. Intrasinusoidal infiltration of the bone marrow also was not specific for SMZL since similar infiltrates, although subtle, also were found in patients with other small B-cell lymphoproliferative disorders, including 6 (55%) of 11 patients whose bone marrow samples were infiltrated by EMZL.

Original languageEnglish (US)
Pages (from-to)698-708
Number of pages11
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 2002


  • Bone marrow
  • Intrasinusoidal infiltration
  • Marginal zone lymphoma
  • Mucosa-associated lymphoid tissue lymphoma
  • Spleen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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