Myoelectric pattern recognition using linear discriminant analysis (LDA) classifiers has been a wellestablished control method for upper limb prostheses for many years. More recently, linear regression (LR) controllers have been proposed as an alternative solution due to their ability to control multiple degrees of freedom (DOF) simultaneously. The aim of this experiment was to compare the online performance of LDA and LR control systems under three electromyographic (EMG) signal conditions: baseline, noise in all channels, and noise in a single channel. To simulate the last two conditions, different levels of Gaussian noise were added to the EMG signals. Completion rate, path efficiency, dwelling time, and completion time were computed after virtual Fitts' Law tasks. While both controllers were significantly affected by the lowest noise levels, we found no significant differences between the controllers under the baseline and all-channel noise conditions. However, the LDA controller outperformed the LR controller in the single-channel noise condition. Therefore, while both controllers are comparable in most cases, the added complexity of simultaneous control affects an LR controller's performance under certain noise conditions. Based on these results, neither control system should be dismissed in future developments.