TY - JOUR
T1 - Comparison between animal and human studies of skeletal muscle adaptation to chronic stimulation
AU - Lieber, R. L.
PY - 1988
Y1 - 1988
N2 - Functional electrical stimulation (FES) has recently emerged as a clinical tool for treatment of neuromuscular disorders. Chronic muscle stimulation, however, has long been used by basic scientists studying the details of the muscular adaptation process. Biochemical, morphological, and functional changes occur in skeletal muscle secondary to chronic stimulation. Chronic stimulation (12-24 hours per day for six weeks) results in a well-defined progression of changes in which a 'fast' muscle becomes a typical 'slow' muscle with a large decrease in force-generating capacity. On the other hand, clinical studies of FES have demonstrated muscle strengthening following treatment. An attempt is made to reconcile the results obtained in the two fields.
AB - Functional electrical stimulation (FES) has recently emerged as a clinical tool for treatment of neuromuscular disorders. Chronic muscle stimulation, however, has long been used by basic scientists studying the details of the muscular adaptation process. Biochemical, morphological, and functional changes occur in skeletal muscle secondary to chronic stimulation. Chronic stimulation (12-24 hours per day for six weeks) results in a well-defined progression of changes in which a 'fast' muscle becomes a typical 'slow' muscle with a large decrease in force-generating capacity. On the other hand, clinical studies of FES have demonstrated muscle strengthening following treatment. An attempt is made to reconcile the results obtained in the two fields.
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U2 - 10.1097/00003086-198808000-00004
DO - 10.1097/00003086-198808000-00004
M3 - Review article
C2 - 3042231
AN - SCOPUS:0023742939
SN - 0009-921X
VL - 233
SP - 19
EP - 24
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
ER -