Abstract
Ionizing radiation exposure during perinatal development can produce various biological effects on the developing offspring. These effects are dependent on a number of factors, including total dose, dose rate and the developmental processes occurring at the time of irradiation. The present study conducted an analysis of historical radiobiological archived data involving 60Co-gamma irradiation of beagle dogs at specific periods of prenatal or postnatal development. The original studies were performed at two sites where animals were exposed to a single, acute dose of 0.2 or 1.0 Gy at six different stages of perinatal development or with protracted exposures ranging from 0.004 to 0.35 Gy per day, over multiple days of gestation. A number of outcomes were investigated after perinatal irradiation including changes in sex ratio, survival probability, disease incidence and growth of animals, based on collected size and weight measurements of animals and different tissues. Protracted irradiations with doses up to 0.35 Gy per day did not significantly affect survival in animals when irradiated prenatally, although significant increases in the incidence of neoplasms and diseases related to the cardiovascular and urogenital system were observed at the time of death. Dogs irradiated at a dose rate of 0.10 Gy per day, with the irradiations continuing after birth and resulting in the accumulation of large total doses, were observed to have chronic radiation syndrome symptoms based on pathologies related to the hematopoietic system. Acute irradiation with 0.2 and 1.0 Gy resulted in changes of different body or tissue sizes measured in animals terminally, with changes detected after irradiation at all tested prenatal and postnatal time points, with the exception of irradiation at 365 days after birth. The present analysis provides new information regarding the biological effects of ionizing radiation during perinatal development in offspring in the unique mammalian study model of the beagle dog.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-82 |
| Number of pages | 10 |
| Journal | Radiation Research |
| Volume | 203 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 24 2025 |
Funding
The authors acknowledge the various research and veterinary staff from ANL and CRHL that conducted all of the original experimentation and analysis that made this work possible. We thank these individuals for the time and dedication that was necessary to coordinate and maintain such large colonies of animals and for performing these experiments over many decades and carefully documenting their efforts. The authors thank Dr. Stephen Benjamin for assistance with access to the CRHL database. The authors also thank Dr. Benjamin Haley for his work on the ANL databases. Funding was provided by a Natural Sciences and Engineering Research Council of Canada-Collaborative Research and Development (NSERC-CRD-CRDPJ/494077-16) grant and the Nuclear Innovation Institute. SS was supported by a NSERC postgraduate graduate scholarship (PGS-D) and the Michael John Page PhD, Graduate Research Award. CL and JP were supported by the Mitacs Accelerate Industrial Postdoctoral Fellowship Program. The CRHL projects were funded by an FDA Contract (Contract# 223-83-6028) from the Center for Devices and Radiological Health, Food and Drug Administration, the Low Level Radiation Effects Branch, Division of Cancer Etiology, National Cancer Institute and Colorado State University. DRB was previously employed by Bruce Power, Ontario, Canada.
ASJC Scopus subject areas
- Biophysics
- Radiation
- Radiology Nuclear Medicine and imaging