Comparison of arterial transit times estimated using arterial spin labeling

Yufen Chen*, Danny J.J. Wang, John A. Detre

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Objective To compare arterial transit time estimates from two efficient transit time mapping techniques using arterial spin labeling (ASL)-flow encoded arterial spin tagging (FEAST) and Look-Locker ASL (LL-ASL). The effects of bipolar gradients and label location were investigated. Materials and methods Six healthy subjects were scanned with pseudo-continuous ASL (pCASL) FEAST and pulsed (PASL) and pCASL variants of LL-ASL at different labeling locations with and without bipolar gradients. Application of transit time mapping was demonstrated in a clinical case. Results Mean (±SD) macrovascular transit times were 363 ± 39, 676 ± 73 and 908 ± 170ms for LL-PASL, LL-pCASL with labeling offsets of 60 and 90mm respectively, showing linear dependence on labeling locations. Mean microvascular transit time for LL-pCASLwas 1,463± 135 ms, in good agreement with the FEAST estimate of 1,444 ± 128 ms. Data acquired from a patient with stroke demonstrate how transit time and CBF maps provide complementary information for clinical diagnosis. Conclusion Both FEAST and LL-ASL provide transit time information in clinically acceptable scan times. Bipolar gradients can be used to tailor transit time estimates for different experimental and clinical situations.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number2
StatePublished - Apr 2012


  • Arterial spin labeling
  • Arterial transit time
  • Cerebral blood flow

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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