Comparison of cimetidine (Tagamet®) with antacid for safety and effectiveness in reducing gastric acidity before elective cesarean section

R. Hodgkinson, R. Glassenberg, T. H. Joyce, D. W. Coombs, G. W. Ostheimer, C. P. Gibbs

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

One hundred twenty-six parturients for elective cesarean section under general anesthesia were allocated to either a cimetidine or an antacid group in a randomized, double-blind, multicenter trial. The cimetidine-treated group received 300 mg cimetidine orally the evening before the operation and 300 mg intramuscularly between 1 and 3 h preoperatively. The antacid-treated group received 30 ml of Mylanta-II® orally on both occasions. Gastric volume, 30 min after induction of anesthesia and 30 min before response to oral commands, was less in the cimetidine-treated group. Gastric pH 30 min after induction was greater in the cimetidine-treated group. The maternal serum level of cimetidine at birth was 1.31 ± 0.12 μg/ml and the umbilical venous level was 0.78 ± 0.05 μg/ml. The neonatal gastric acidity, Apgar scores, and Early Neonatal Neurobehavioral Scale (ENNS) scores were similar in both groups. No maternal or neonatal complication was attributed to treatment.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalUnknown Journal
Volume59
Issue number2
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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