Comparison of filtration leukapheresis and centrifugation leukapheresis in treatment of lymphosarcoma cell leukemia

Philip C. Amrein*, Joan R. Kumar, Ronald F. Poulin, Joel Umlas, Sigmund A. Weitzman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with lymphosarcoma cell leukemia resistant to chemotherapy was treated with filtration leukapheresis and centrifugation leukapheresis. Filtration leukapheresis removed only 10n leukemia cells per 8.5 liters of blood processed, while centrifugation leukapheresis removed approximately six times as many leukemia cells from the same amount of blood. Lymph nodes and spleen diminished in size and the WBC count decreased after nine treatments. However, the patient remained markedly thrombocytopenic, and his bone marrow remained infiltrated with lymphosarcoma cells on repeat biopsy. This study shows that centrifugation leukapheresis is superior to filtration leukapheresis in removing significant numbers of circulating lymphosarcoma cells, though the clinical benefit of leukapheresis in this situation remains to be determined.

Original languageEnglish (US)
Pages (from-to)969-971
Number of pages3
JournalSouthern Medical Journal
Volume75
Issue number8
DOIs
StatePublished - Aug 1982

ASJC Scopus subject areas

  • Medicine(all)

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