Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping

Thomas A. Hope, Michael Markl, Lars Wigström, Marcus T. Alley, D. Craig Miller, Robert J. Herfkens*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

Purpose: To determine the difference in flow patterns between healthy volunteers and ascending aortic aneurysm patients using time-resolved three-dimensional (3D) phase contrast magnetic resonance velocity (4D-flow) profiling. Materials and Methods: 4D-flow was performed on 19 healthy volunteers and 13 patients with ascending aortic aneurysms. Vector fields placed on 2D planes were visually graded to analyze helical and retrograde flow patterns along the aortic arch. Quantitative analysis of the pulsatile flow was carried out on manually segmented planes. Results: In volunteers, flow progressed as follows: an initial jet of blood skewed toward the anterior right wall of the ascending aorta is reflected posterolaterally toward the inner curvature creating opposing helices, a right-handed helix along the left wall and a left-handed helix along the right wall; retrograde flow occurred in all volunteers along the inner curvature between the location of the two helices. In the aneurysm patients, the helices were larger; retrograde flow occurred earlier and lasted longer. The average velocity decreased between the ascending aorta and the transverse aorta in volunteers (47.9 mm/second decrease, P = 0.023), while in aneurysm patients the velocity increased (145 mm/second increase, P < 0.001). Conclusion: Dilation of the ascending aorta skews normal flow in the ascending aorta, changing retrograde and helical flow patterns.

Original languageEnglish (US)
Pages (from-to)1471-1479
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume26
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Ascending aortic aneurysms
  • Cardiac
  • Flow
  • Magnetic resonance imaging
  • Phase contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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