Comparison of health inequalities between East and West Germany

Pediatric AIDS Clinical Trials Group

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The pharmacokinetics, safety, tolerance, and antiviral effects of ganciclovir (Gcv) administered orally were evaluated in 36 children infected with cytomegalovirus (CMV) who were severely immunocompromised by infection with human immunodeficiency virus type 1. In this dose-escalation study, 30 mg/kg of Gcv administered every 8 h produced serum levels similar to the dose (1 g/8 h) effective for maintenance treatment of CMV retinitis in adults. In older children, serum Gcv concentrations were similar after the administration of capsules and suspension. All doses (10-50 mg/kg/8 h) studied were safe and, except for the volume of suspension or number of pills, were well tolerated. Oral Gcv was associated with a decrease in the detection of CMV by culture or polymerase chain reaction. CMV disease occurred in 3 children during the study: one developed Gcv resistance, another had harbored resistant virus at study entry, and a third had wild-type CMV.

Original languageEnglish (US)
Pages (from-to)262-267
Number of pages6
JournalEuropean journal of public health
Volume10
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Germany
  • Health inequalities
  • Income inequalities

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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