Comparison of ketamine and thiopental in healthy volunteers: Effects on mental status, mood, and personality

R. J. Moretti, S. Z. Hassan, L. I. Goodman, Herbert Y Meltzer

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The purpose of this study was to compare the psychological effects of ketamine and thiopental anesthesia. In a double-blind comparison, 20 normal female volunteers were given 2.5 mg/kg ketamine intravenously and 20 were given 5.0 mg/kg thiopental intravenously. Subjects were assessed with a variety of objective and subjective psychological measures before, immediately after, and 24 hr, 2 weeks, and 4 months after anesthesia. Immediately after anesthesia, there was a significantly greater incidence of abnormalities of mental status in subjects given ketamine than in those who had received thiopental. Changes were generally short-lived and were no longer evident on the following day. No significant differences were found between the two groups with regard to long-term changes in personality. Changes in mental status are attributed to the slower, more uneven return to consciousness of the subjects receiving ketamine.

Original languageEnglish (US)
Pages (from-to)1087-1096
Number of pages10
JournalAnesthesia and Analgesia
Volume63
Issue number12
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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