TY - JOUR
T1 - Comparison of Patient-Oriented Eczema Measure and Patient-Oriented Scoring Atopic Dermatitis vs Eczema Area and Severity Index and other measures of atopic dermatitis
T2 - A validation study
AU - Silverberg, Jonathan I
AU - Lei, Donald
AU - Yousaf, Muhammad
AU - Janmohamed, Sherief R.
AU - Vakharia, Paras P.
AU - Chopra, Rishi
AU - Chavda, Rajeev
AU - Gabriel, Sylvie
AU - Patel, Kevin R.
AU - Singam, Vivek
AU - Kantor, Robert
AU - Hsu, Derek Y.
N1 - Funding Information:
Funding Sources: This publication was made possible with support from the Agency for Healthcare Research and Quality ( AHRQ , grant number K12 HS023011 ), the Dermatology Foundation , and an unrestricted research grant from Galderma .
Publisher Copyright:
© 2020 American College of Allergy, Asthma & Immunology
PY - 2020/7
Y1 - 2020/7
N2 - Background: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM). Objective: To examine the measurement properties of PO-SCORAD and compare them with those of POEM. Methods: A prospective dermatology practice–based study of 291 patients with AD (age range, 18-72 years). Results: PO-SCORAD and POEM were moderately correlated with each other (Spearman ρ = 0.56) and had weak-moderate correlations with the Numeric Rating Scale (NRS) worst itch and average itch, Dermatology Life Quality Index (DLQI), ItchyQOL, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance (SD) and Sleep-Related Impairment (SRI), Patient Health Questionnaire-9 (PHQ-9), and Eczema Area and Severity Index (EASI) (P < .001). POEM had significantly stronger correlations with DLQI, ItchyQOL, and EASI than did PO-SCORAD. PO-SCORAD and POEM had fair discriminant validity. Changes from baseline in PO-SCORAD and POEM were moderately correlated with each other; were weakly to strongly correlated with NRS worst itch and average itch, DLQI, ItchyQOL, PROMIS SD, PROMIS SRI, PHQ-9, and EASI; and had good test-retest reliability. There was no differential item functioning of items or floor or ceiling effects for PO-SCORAD or POEM. The thresholds for meaningful change for PO-SCORAD and POEM were −15.5 and −5.0, respectively. Median completion times for PO-SCORAD and POEM were 3 minutes and 1 minute, respectively. Conclusion: PO-SCORAD and POEM had good construct and cross-cultural validity, reliability, and responsiveness in adults with AD and were feasible for use in clinical trials and practice. However, POEM had better measurement properties than PO-SCORAD.
AB - Background: Little is known about the measurement properties of Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) in adults with atopic dermatitis (AD). Even less is known about how PO-SCORAD performs compared with the Patient-Oriented Eczema Measure (POEM). Objective: To examine the measurement properties of PO-SCORAD and compare them with those of POEM. Methods: A prospective dermatology practice–based study of 291 patients with AD (age range, 18-72 years). Results: PO-SCORAD and POEM were moderately correlated with each other (Spearman ρ = 0.56) and had weak-moderate correlations with the Numeric Rating Scale (NRS) worst itch and average itch, Dermatology Life Quality Index (DLQI), ItchyQOL, Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance (SD) and Sleep-Related Impairment (SRI), Patient Health Questionnaire-9 (PHQ-9), and Eczema Area and Severity Index (EASI) (P < .001). POEM had significantly stronger correlations with DLQI, ItchyQOL, and EASI than did PO-SCORAD. PO-SCORAD and POEM had fair discriminant validity. Changes from baseline in PO-SCORAD and POEM were moderately correlated with each other; were weakly to strongly correlated with NRS worst itch and average itch, DLQI, ItchyQOL, PROMIS SD, PROMIS SRI, PHQ-9, and EASI; and had good test-retest reliability. There was no differential item functioning of items or floor or ceiling effects for PO-SCORAD or POEM. The thresholds for meaningful change for PO-SCORAD and POEM were −15.5 and −5.0, respectively. Median completion times for PO-SCORAD and POEM were 3 minutes and 1 minute, respectively. Conclusion: PO-SCORAD and POEM had good construct and cross-cultural validity, reliability, and responsiveness in adults with AD and were feasible for use in clinical trials and practice. However, POEM had better measurement properties than PO-SCORAD.
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U2 - 10.1016/j.anai.2020.03.006
DO - 10.1016/j.anai.2020.03.006
M3 - Article
C2 - 32199977
AN - SCOPUS:85082856109
VL - 125
SP - 78
EP - 83
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
SN - 1081-1206
IS - 1
ER -