Comparison of Pediatric and Adult Solid Pseudopapillary Neoplasms of the Pancreas

CCDR Group

Research output: Contribution to journalArticle

Abstract

Background: Solid pseudopapillary neoplasms (SPPNs) comprise the majority of pediatric pancreatic neoplasms. We queried the National Cancer Database to compare pediatric and adult patients with SSPNs to examine differences in demographics, tumor characteristics, treatment, and overall survival. We aimed to determine if survival differences existed between adult and pediatric patients with SPPN. Methods: The National Cancer Database (2004-2014) was reviewed, and patients were stratified by age at diagnosis: pediatric (≤21 y) and adult (≥22 y). Demographics, comorbidities, tumor characteristics, diagnostic periods, treatments, and survival rates were compared using pooled variance t-tests and chi-square, followed by multivariate Cox proportional hazard model (α = 0.05). Log-rank test was used to compare survival. Results: A total of 468 patients were analyzed and categorized according to age group. Four hundred and fourteen patients were included in the survival analysis. The pediatric patients were primarily female, Caucasian, had no comorbidities, and presented with stage I disease. Race/ethnicity, gender, socioeconomic status, comorbidities, and disease stage at presentation were similar between the groups. There was no difference in time to initiation of therapy or to surgical intervention. No significant difference was found in type of surgical resection, chemotherapy, or radiotherapy utilization. Despite the similarities between groups, comparison of overall survival demonstrated improved survival of pediatric SPPN compared with adult SPPN in every pathologic stage. Conclusions: These results suggest that pediatric and adult SPPNs are similar with regards to demographics, tumor characteristics, and treatment modalities. However, survival was better in children with SPPNs, which may be due to differences in tumor biology and may serve for risk stratification of prognosis.

Original languageEnglish (US)
Pages (from-to)312-317
Number of pages6
JournalJournal of Surgical Research
Volume242
DOIs
StatePublished - Oct 1 2019

Fingerprint

Pancreatic Neoplasms
Pediatrics
Neoplasms
Survival
Comorbidity
Demography
Databases
Chi-Square Distribution
Therapeutics
Survival Analysis
Proportional Hazards Models
Social Class
Radiotherapy
Survival Rate
Age Groups
Drug Therapy

Keywords

  • Neoplasm
  • Pancreas
  • Pediatric
  • SPPN

ASJC Scopus subject areas

  • Surgery

Cite this

@article{5fe03ac37fc040ce84072b43b4f1581e,
title = "Comparison of Pediatric and Adult Solid Pseudopapillary Neoplasms of the Pancreas",
abstract = "Background: Solid pseudopapillary neoplasms (SPPNs) comprise the majority of pediatric pancreatic neoplasms. We queried the National Cancer Database to compare pediatric and adult patients with SSPNs to examine differences in demographics, tumor characteristics, treatment, and overall survival. We aimed to determine if survival differences existed between adult and pediatric patients with SPPN. Methods: The National Cancer Database (2004-2014) was reviewed, and patients were stratified by age at diagnosis: pediatric (≤21 y) and adult (≥22 y). Demographics, comorbidities, tumor characteristics, diagnostic periods, treatments, and survival rates were compared using pooled variance t-tests and chi-square, followed by multivariate Cox proportional hazard model (α = 0.05). Log-rank test was used to compare survival. Results: A total of 468 patients were analyzed and categorized according to age group. Four hundred and fourteen patients were included in the survival analysis. The pediatric patients were primarily female, Caucasian, had no comorbidities, and presented with stage I disease. Race/ethnicity, gender, socioeconomic status, comorbidities, and disease stage at presentation were similar between the groups. There was no difference in time to initiation of therapy or to surgical intervention. No significant difference was found in type of surgical resection, chemotherapy, or radiotherapy utilization. Despite the similarities between groups, comparison of overall survival demonstrated improved survival of pediatric SPPN compared with adult SPPN in every pathologic stage. Conclusions: These results suggest that pediatric and adult SPPNs are similar with regards to demographics, tumor characteristics, and treatment modalities. However, survival was better in children with SPPNs, which may be due to differences in tumor biology and may serve for risk stratification of prognosis.",
keywords = "Neoplasm, Pancreas, Pediatric, SPPN",
author = "{CCDR Group} and Waters, {Alicia M.} and Russell, {Robert T.} and Maizlin, {Ilan I.} and Dellinger, {Matthew B.} and Gow, {Kenneth W.} and Ankush Gosain and Monica Langer and Raval, {Mehul V} and Nuchtern, {Jed G.} and Doski, {John J.} and Vasudevan, {Sanjeev A.} and Beierle, {Elizabeth A.}",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.jss.2019.04.070",
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volume = "242",
pages = "312--317",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",

}

Comparison of Pediatric and Adult Solid Pseudopapillary Neoplasms of the Pancreas. / CCDR Group.

In: Journal of Surgical Research, Vol. 242, 01.10.2019, p. 312-317.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of Pediatric and Adult Solid Pseudopapillary Neoplasms of the Pancreas

AU - CCDR Group

AU - Waters, Alicia M.

AU - Russell, Robert T.

AU - Maizlin, Ilan I.

AU - Dellinger, Matthew B.

AU - Gow, Kenneth W.

AU - Gosain, Ankush

AU - Langer, Monica

AU - Raval, Mehul V

AU - Nuchtern, Jed G.

AU - Doski, John J.

AU - Vasudevan, Sanjeev A.

AU - Beierle, Elizabeth A.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Solid pseudopapillary neoplasms (SPPNs) comprise the majority of pediatric pancreatic neoplasms. We queried the National Cancer Database to compare pediatric and adult patients with SSPNs to examine differences in demographics, tumor characteristics, treatment, and overall survival. We aimed to determine if survival differences existed between adult and pediatric patients with SPPN. Methods: The National Cancer Database (2004-2014) was reviewed, and patients were stratified by age at diagnosis: pediatric (≤21 y) and adult (≥22 y). Demographics, comorbidities, tumor characteristics, diagnostic periods, treatments, and survival rates were compared using pooled variance t-tests and chi-square, followed by multivariate Cox proportional hazard model (α = 0.05). Log-rank test was used to compare survival. Results: A total of 468 patients were analyzed and categorized according to age group. Four hundred and fourteen patients were included in the survival analysis. The pediatric patients were primarily female, Caucasian, had no comorbidities, and presented with stage I disease. Race/ethnicity, gender, socioeconomic status, comorbidities, and disease stage at presentation were similar between the groups. There was no difference in time to initiation of therapy or to surgical intervention. No significant difference was found in type of surgical resection, chemotherapy, or radiotherapy utilization. Despite the similarities between groups, comparison of overall survival demonstrated improved survival of pediatric SPPN compared with adult SPPN in every pathologic stage. Conclusions: These results suggest that pediatric and adult SPPNs are similar with regards to demographics, tumor characteristics, and treatment modalities. However, survival was better in children with SPPNs, which may be due to differences in tumor biology and may serve for risk stratification of prognosis.

AB - Background: Solid pseudopapillary neoplasms (SPPNs) comprise the majority of pediatric pancreatic neoplasms. We queried the National Cancer Database to compare pediatric and adult patients with SSPNs to examine differences in demographics, tumor characteristics, treatment, and overall survival. We aimed to determine if survival differences existed between adult and pediatric patients with SPPN. Methods: The National Cancer Database (2004-2014) was reviewed, and patients were stratified by age at diagnosis: pediatric (≤21 y) and adult (≥22 y). Demographics, comorbidities, tumor characteristics, diagnostic periods, treatments, and survival rates were compared using pooled variance t-tests and chi-square, followed by multivariate Cox proportional hazard model (α = 0.05). Log-rank test was used to compare survival. Results: A total of 468 patients were analyzed and categorized according to age group. Four hundred and fourteen patients were included in the survival analysis. The pediatric patients were primarily female, Caucasian, had no comorbidities, and presented with stage I disease. Race/ethnicity, gender, socioeconomic status, comorbidities, and disease stage at presentation were similar between the groups. There was no difference in time to initiation of therapy or to surgical intervention. No significant difference was found in type of surgical resection, chemotherapy, or radiotherapy utilization. Despite the similarities between groups, comparison of overall survival demonstrated improved survival of pediatric SPPN compared with adult SPPN in every pathologic stage. Conclusions: These results suggest that pediatric and adult SPPNs are similar with regards to demographics, tumor characteristics, and treatment modalities. However, survival was better in children with SPPNs, which may be due to differences in tumor biology and may serve for risk stratification of prognosis.

KW - Neoplasm

KW - Pancreas

KW - Pediatric

KW - SPPN

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