Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors

A. B. Kornblith; J. E. Herndon; E. Zuckerman; D. F. Cella; E. Cherin; S. Wolchok; R. B. Weiss; L. F. Diehl; E. Henderson; M. R. Cooper; C. Schiffer; G. P. Canellos; R. J. Mayer; R. T. Silver; A. Schilling; B. A. Peterson; D. Greenberg; J. C. Holland

doi:10.1023/A:1008297130258

Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors

A. B. Kornblith^*, J. E. Herndon, E. Zuckerman, D. F. Cella, E. Cherin, S. Wolchok, R. B. Weiss, L. F. Diehl, E. Henderson, M. R. Cooper, C. Schiffer, G. P. Canellos, R. J. Mayer, R. T. Silver, A. Schilling, B. A. Peterson, D. Greenberg, J. C. Holland

^*Corresponding author for this work

Medical Social Sciences

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Abstract

Background: The purpose of this study was to compare the long-term psychosocial adaptation of Hodgkin's disease and adult acute leukemia survivors. Patients and methods: Two hundred seventy-three Hodgkin's disease (HD) and 206 adult acute leukemia (AL) survivors were interviewed by telephone concerning their psychosocial adjustment and problems they attributed to having been treated for cancer, using identical research procedures and a common set of instruments. The following measures were used: Psychosocial Adjustment to Illness Scale (PAIS); Brief Symptom Inventory (BSI); current Conditioned Nausea and Vomiting triggered by treatment- related stimuli (CNVI); Indices of Employment, Insurance and Sexual Problems Attributed to Cancer; Negative Socioeconomic Impact of Cancer Index (NSI). All participants had been treated on one of nine Hodgkin's disease or 13 acute leukemia Cancer and Leukemia Group B (CALGB) clinical trials from 1966- 1988, and had been off treatment for one year or more (mean years: HD = 5.9; AL = 5.6). Results: HD survivors' risk of having a high distress score on the BSI was almost twice that found for AL survivors (odds ratio = 1.90), with 21% of HD vs. 14% of AL survivors (P < 0.05) having scores that were 1.5 standard deviations above the norm, suggestive of a possible psychiatric disorder. HD survivors reported greater fatigue (POMS Fatigue, P = 0.01; Vigor Subscales, P = 0.001), greater conditioned nausea (CNVI, P < 0.05), greater impact of cancer on their family life (PAIS Domestic Environment, P = 0.004) and poorer sexual functioning (PAIS Sexual Relationships, P = 0.0001), than AL survivors. Conclusions: Treatment-related issues may have placed HD survivors at a greater risk for problems in long-term adaptation than AL survivors.

Original language	English (US)
Pages (from-to)	297-306
Number of pages	10
Journal	Annals of Oncology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1023/A:1008297130258
State	Published - Mar 1998

Keywords

Adaptation
Adjustment
Cancer survivors
Hodgkin's disease
Leukemia
Quality of life

ASJC Scopus subject areas

Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1008297130258

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Kornblith, A. B., Herndon, J. E., Zuckerman, E., Cella, D. F., Cherin, E., Wolchok, S., Weiss, R. B., Diehl, L. F., Henderson, E., Cooper, M. R., Schiffer, C., Canellos, G. P., Mayer, R. J., Silver, R. T., Schilling, A., Peterson, B. A., Greenberg, D., & Holland, J. C. (1998). Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Annals of Oncology, 9(3), 297-306. https://doi.org/10.1023/A:1008297130258

@article{66e7bd25d3a642749be753cdaf4881cb,

title = "Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors",

abstract = "Background: The purpose of this study was to compare the long-term psychosocial adaptation of Hodgkin's disease and adult acute leukemia survivors. Patients and methods: Two hundred seventy-three Hodgkin's disease (HD) and 206 adult acute leukemia (AL) survivors were interviewed by telephone concerning their psychosocial adjustment and problems they attributed to having been treated for cancer, using identical research procedures and a common set of instruments. The following measures were used: Psychosocial Adjustment to Illness Scale (PAIS); Brief Symptom Inventory (BSI); current Conditioned Nausea and Vomiting triggered by treatment- related stimuli (CNVI); Indices of Employment, Insurance and Sexual Problems Attributed to Cancer; Negative Socioeconomic Impact of Cancer Index (NSI). All participants had been treated on one of nine Hodgkin's disease or 13 acute leukemia Cancer and Leukemia Group B (CALGB) clinical trials from 1966- 1988, and had been off treatment for one year or more (mean years: HD = 5.9; AL = 5.6). Results: HD survivors' risk of having a high distress score on the BSI was almost twice that found for AL survivors (odds ratio = 1.90), with 21% of HD vs. 14% of AL survivors (P < 0.05) having scores that were 1.5 standard deviations above the norm, suggestive of a possible psychiatric disorder. HD survivors reported greater fatigue (POMS Fatigue, P = 0.01; Vigor Subscales, P = 0.001), greater conditioned nausea (CNVI, P < 0.05), greater impact of cancer on their family life (PAIS Domestic Environment, P = 0.004) and poorer sexual functioning (PAIS Sexual Relationships, P = 0.0001), than AL survivors. Conclusions: Treatment-related issues may have placed HD survivors at a greater risk for problems in long-term adaptation than AL survivors.",

keywords = "Adaptation, Adjustment, Cancer survivors, Hodgkin's disease, Leukemia, Quality of life",

author = "Kornblith, {A. B.} and Herndon, {J. E.} and E. Zuckerman and Cella, {D. F.} and E. Cherin and S. Wolchok and Weiss, {R. B.} and Diehl, {L. F.} and E. Henderson and Cooper, {M. R.} and C. Schiffer and Canellos, {G. P.} and Mayer, {R. J.} and Silver, {R. T.} and A. Schilling and Peterson, {B. A.} and D. Greenberg and Holland, {J. C.}",

year = "1998",

month = mar,

doi = "10.1023/A:1008297130258",

language = "English (US)",

volume = "9",

pages = "297--306",

journal = "Annals of Oncology",

issn = "0923-7534",

publisher = "Oxford University Press",

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Kornblith, AB, Herndon, JE, Zuckerman, E, Cella, DF, Cherin, E, Wolchok, S, Weiss, RB, Diehl, LF, Henderson, E, Cooper, MR, Schiffer, C, Canellos, GP, Mayer, RJ, Silver, RT, Schilling, A, Peterson, BA, Greenberg, D & Holland, JC 1998, 'Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors', Annals of Oncology, vol. 9, no. 3, pp. 297-306. https://doi.org/10.1023/A:1008297130258

TY - JOUR

T1 - Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors

AU - Kornblith, A. B.

AU - Herndon, J. E.

AU - Zuckerman, E.

AU - Cella, D. F.

AU - Cherin, E.

AU - Wolchok, S.

AU - Weiss, R. B.

AU - Diehl, L. F.

AU - Henderson, E.

AU - Cooper, M. R.

AU - Schiffer, C.

AU - Canellos, G. P.

AU - Mayer, R. J.

AU - Silver, R. T.

AU - Schilling, A.

AU - Peterson, B. A.

AU - Greenberg, D.

AU - Holland, J. C.

PY - 1998/3

Y1 - 1998/3

N2 - Background: The purpose of this study was to compare the long-term psychosocial adaptation of Hodgkin's disease and adult acute leukemia survivors. Patients and methods: Two hundred seventy-three Hodgkin's disease (HD) and 206 adult acute leukemia (AL) survivors were interviewed by telephone concerning their psychosocial adjustment and problems they attributed to having been treated for cancer, using identical research procedures and a common set of instruments. The following measures were used: Psychosocial Adjustment to Illness Scale (PAIS); Brief Symptom Inventory (BSI); current Conditioned Nausea and Vomiting triggered by treatment- related stimuli (CNVI); Indices of Employment, Insurance and Sexual Problems Attributed to Cancer; Negative Socioeconomic Impact of Cancer Index (NSI). All participants had been treated on one of nine Hodgkin's disease or 13 acute leukemia Cancer and Leukemia Group B (CALGB) clinical trials from 1966- 1988, and had been off treatment for one year or more (mean years: HD = 5.9; AL = 5.6). Results: HD survivors' risk of having a high distress score on the BSI was almost twice that found for AL survivors (odds ratio = 1.90), with 21% of HD vs. 14% of AL survivors (P < 0.05) having scores that were 1.5 standard deviations above the norm, suggestive of a possible psychiatric disorder. HD survivors reported greater fatigue (POMS Fatigue, P = 0.01; Vigor Subscales, P = 0.001), greater conditioned nausea (CNVI, P < 0.05), greater impact of cancer on their family life (PAIS Domestic Environment, P = 0.004) and poorer sexual functioning (PAIS Sexual Relationships, P = 0.0001), than AL survivors. Conclusions: Treatment-related issues may have placed HD survivors at a greater risk for problems in long-term adaptation than AL survivors.

AB - Background: The purpose of this study was to compare the long-term psychosocial adaptation of Hodgkin's disease and adult acute leukemia survivors. Patients and methods: Two hundred seventy-three Hodgkin's disease (HD) and 206 adult acute leukemia (AL) survivors were interviewed by telephone concerning their psychosocial adjustment and problems they attributed to having been treated for cancer, using identical research procedures and a common set of instruments. The following measures were used: Psychosocial Adjustment to Illness Scale (PAIS); Brief Symptom Inventory (BSI); current Conditioned Nausea and Vomiting triggered by treatment- related stimuli (CNVI); Indices of Employment, Insurance and Sexual Problems Attributed to Cancer; Negative Socioeconomic Impact of Cancer Index (NSI). All participants had been treated on one of nine Hodgkin's disease or 13 acute leukemia Cancer and Leukemia Group B (CALGB) clinical trials from 1966- 1988, and had been off treatment for one year or more (mean years: HD = 5.9; AL = 5.6). Results: HD survivors' risk of having a high distress score on the BSI was almost twice that found for AL survivors (odds ratio = 1.90), with 21% of HD vs. 14% of AL survivors (P < 0.05) having scores that were 1.5 standard deviations above the norm, suggestive of a possible psychiatric disorder. HD survivors reported greater fatigue (POMS Fatigue, P = 0.01; Vigor Subscales, P = 0.001), greater conditioned nausea (CNVI, P < 0.05), greater impact of cancer on their family life (PAIS Domestic Environment, P = 0.004) and poorer sexual functioning (PAIS Sexual Relationships, P = 0.0001), than AL survivors. Conclusions: Treatment-related issues may have placed HD survivors at a greater risk for problems in long-term adaptation than AL survivors.

KW - Adaptation

KW - Adjustment

KW - Cancer survivors

KW - Hodgkin's disease

KW - Leukemia

KW - Quality of life

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DO - 10.1023/A:1008297130258

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SN - 0923-7534

VL - 9

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JO - Annals of Oncology

JF - Annals of Oncology

IS - 3

ER -

Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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