Comparison of seven heterophile antibody assays for laboratory diagnosis of infectious mononucleosis in pediatric patients

Sharon Wei; Wei Huang; Mohamed Farah; Aaruni Khanolkar; Xiaotian Zheng

doi:10.1002/jmv.27254

Comparison of seven heterophile antibody assays for laboratory diagnosis of infectious mononucleosis in pediatric patients

Sharon Wei, Wei Huang, Mohamed Farah, Aaruni Khanolkar, Xiaotian Zheng^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Heterophile antibody assays have been used to aid the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus. Seven commercially available assays currently widely utilized in clinical laboratories were compared in this study. Variable performance characteristics and assay times are observed, and these pieces of data may assist clinical laboratories in assay selection and result interpretation.

Original language	English (US)
Pages (from-to)	6404-6407
Number of pages	4
Journal	Journal of Medical Virology
Volume	93
Issue number	11
DOIs	https://doi.org/10.1002/jmv.27254
State	Published - Nov 2021

Funding

The authors thank the following experts for their helpful comments and suggestions for the study: Alexandra Vardouniotis, Lela Buckingham, and Nadine Lerret. We thank the staff in Immunology and Microbiology laboratories at Lurie Children's for their technical assistance. We thank the following manufacturers: Abbott U.S., Biokit, Inova Diagnostics, LifeSign, Sekisui Diagnostics, and Trinity Biotech for providing the assay kits used in this study.

Keywords

EBV
heterophile antibody
infectious mononucleosis

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.27254

Cite this

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abstract = "Heterophile antibody assays have been used to aid the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus. Seven commercially available assays currently widely utilized in clinical laboratories were compared in this study. Variable performance characteristics and assay times are observed, and these pieces of data may assist clinical laboratories in assay selection and result interpretation.",

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AU - Huang, Wei

AU - Farah, Mohamed

AU - Khanolkar, Aaruni

AU - Zheng, Xiaotian

N1 - Funding Information: The authors thank the following experts for their helpful comments and suggestions for the study: Alexandra Vardouniotis, Lela Buckingham, and Nadine Lerret. We thank the staff in Immunology and Microbiology laboratories at Lurie Children's for their technical assistance. We thank the following manufacturers: Abbott U.S., Biokit, Inova Diagnostics, LifeSign, Sekisui Diagnostics, and Trinity Biotech for providing the assay kits used in this study. Publisher Copyright: © 2021 Wiley Periodicals LLC

PY - 2021/11

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N2 - Heterophile antibody assays have been used to aid the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus. Seven commercially available assays currently widely utilized in clinical laboratories were compared in this study. Variable performance characteristics and assay times are observed, and these pieces of data may assist clinical laboratories in assay selection and result interpretation.

AB - Heterophile antibody assays have been used to aid the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus. Seven commercially available assays currently widely utilized in clinical laboratories were compared in this study. Variable performance characteristics and assay times are observed, and these pieces of data may assist clinical laboratories in assay selection and result interpretation.

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KW - infectious mononucleosis

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Comparison of seven heterophile antibody assays for laboratory diagnosis of infectious mononucleosis in pediatric patients

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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