TY - JOUR
T1 - Comparison of swallowing function after intensity-modulated radiation therapy and conventional radiotherapy for head and neck cancer
AU - Pauloski, Barbara Roa
AU - Rademaker, Alfred W.
AU - Logemann, Jerilyn A.
AU - Discekici-Harris, Muveddet
AU - Mittal, Bharat B.
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc. Head Neck 37: 1575-1582, 2015.
PY - 2015/11
Y1 - 2015/11
N2 - Background Intensity-modulated radiotherapy (IMRT) is hoped to protect structures important for swallow function. We compared posttreatment swallow function in 7 pairs of patients with head and neck cancer treated with either IMRT or conventional radiotherapy (RT). Methods Patients were matched on tumor characteristics. Swallowing function was evaluated with the modified barium swallow procedure pretreatment and at 3 and 6 months postcancer treatment completion. Swallows were analyzed for bolus transit times, bolus residues, laryngeal closure (LAC) duration, cricopharyngeal opening (CPO) duration, and oropharyngeal swallow efficiency (OPSE). Data were analyzed using multifactor repeated measures analysis of variance and adjusted for baseline function. Results Main effect of radiation type was significant for all measures on at least 1 bolus type. Patients treated with IMRT demonstrated shorter bolus transit times, less oral and pharyngeal residue, longer LAC, and larger OPSE. Conclusion Patients treated with IMRT demonstrated faster, more efficient swallows, and greater airway protection.
AB - Background Intensity-modulated radiotherapy (IMRT) is hoped to protect structures important for swallow function. We compared posttreatment swallow function in 7 pairs of patients with head and neck cancer treated with either IMRT or conventional radiotherapy (RT). Methods Patients were matched on tumor characteristics. Swallowing function was evaluated with the modified barium swallow procedure pretreatment and at 3 and 6 months postcancer treatment completion. Swallows were analyzed for bolus transit times, bolus residues, laryngeal closure (LAC) duration, cricopharyngeal opening (CPO) duration, and oropharyngeal swallow efficiency (OPSE). Data were analyzed using multifactor repeated measures analysis of variance and adjusted for baseline function. Results Main effect of radiation type was significant for all measures on at least 1 bolus type. Patients treated with IMRT demonstrated shorter bolus transit times, less oral and pharyngeal residue, longer LAC, and larger OPSE. Conclusion Patients treated with IMRT demonstrated faster, more efficient swallows, and greater airway protection.
KW - conventional radiotherapy
KW - dysphagia
KW - head and neck cancer
KW - intensity-modulated radiation therapy (IMRT)
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U2 - 10.1002/hed.23796
DO - 10.1002/hed.23796
M3 - Article
C2 - 24909649
AN - SCOPUS:84944148731
VL - 37
SP - 1575
EP - 1582
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 11
ER -