Comparison of tacrolimus with microemulsion cyclosporine as primary immunosuppression in hepatitis C patients after liver transplantation

Xaralambos A. Zervos*, Deborah Weppler, Georgios P. Fragulidis, Maria B. Torres, Jose R. Nery, Mohammed F. Khan, Antonio D. Pinna, Tomoaki Kato, Joshua Miller, K. Rajender Reddy, Andreas G. Tzakis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Background. Immunosuppression in patients with hepatitis C virus (HCV) following orthotopic liver transplantation can lead to significant increases in serum viral loads. Our aim was to analyze the effect of a randomized study of two immunosuppressive agents (tacrolimus vs. microemulsion cyclosporine) on the outcome of HCV patients following orthotopic liver transplantation. Methods. From December 1995 to September 1996, 50 adult patients transplanted for HCV cirrhosis were randomly assigned to receive tacrolimus (Prograf) (group 1, 25 patients) or microemulsion cyclosporine (Neoral) (group 2, 24 patients). All patients received α-interferon after transplantation, and the overall steroid doses were no different between the groups. Serum RNA levels were measured by signal amplification of Chiron. Biopsies were taken when transaminases were greater than 2x base line or when there was an inappropriate response to alterations in immunosuppression regimens. Results. There were more episodes of rejection in the Neoral group, but there were no differences in bacterial and vital infections, nor in the rate of HCV recurrence between the two groups. There were seven deaths in group 1 and eight in group 2. Overall patient and graft survival rates in the Prograf and Neoral groups at 18 months were 72 and 68% and 67 and 64%, respectively. Conclusions. (a) Both immunosuppression regimens had similar HCV recurrence rates; (b) there were no differences in bacterial or opportunistic infections; and (c) patient and graft survival was similar between the two groups.

Original languageEnglish (US)
Pages (from-to)1044-1046
Number of pages3
Issue number8
StatePublished - Apr 27 1998

ASJC Scopus subject areas

  • Transplantation


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