@inproceedings{98c3f791fee1482a9eb4f61c27f63afe,
title = "Comparison of temporal properties of auditory single units in response to cochlear infrared laser stimulation recorded with multi-channel and single tungsten electrodes",
abstract = "Auditory prostheses may benefit from Infrared Neural Stimulation (INS) because optical stimulation allows for spatially selective activation of neuron populations. Selective activation of neurons in the cochlear spiral ganglion can be determined in the central nucleus of the inferior colliculus (ICC) because the tonotopic organization of frequencies in the cochlea is maintained throughout the auditory pathway. The activation profile of INS is well represented in the ICC by multichannel electrodes (MCEs). To characterize single unit properties in response to INS, however, single tungsten electrodes (STEs) should be used because of its better signal-to-noise ratio. In this study, we compared the temporal properties of ICC single units recorded with MCEs and STEs in order to characterize the response properties of single auditory neurons in response to INS in guinea pigs. The length along the cochlea stimulated with infrared radiation corresponded to a frequency range of about 0.6 octaves, similar to that recorded with STEs. The temporal properties of single units recorded with MCEs showed higher maximum rates, shorter latencies, and higher firing efficiencies compared to those recorded with STEs. When the preset amplitude threshold for triggering MCE recordings was raised to twice over the noise level, the temporal properties of the single units became similar to those obtained with STEs. Undistinguishable neural activities from multiple sources in MCE recordings could be responsible for the response property difference between MCEs and STEs. Thus, caution should be taken in single unit recordings with MCEs.",
keywords = "Hearing, Inferior colliculus, Infrared neural stimulation, Multichannel electrodes, Tungsten electrodes",
author = "Xiaodong Tan and Nan Xia and Hunter Young and Richter, {Claus Peter}",
year = "2015",
doi = "10.1117/12.2178046",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Kang, {Hyun Wook} and Ilgner, {Justus F.} and Skala, {Melissa C.} and Laura Marcu and Haishan Zeng and Dewhirst, {Mark W.} and Gregory, {Kenton W.} and Andreas Mandelis and Bernard Choi and Wong, {Brian Jet-Fei} and Claus-Peter Richter and Tearney, {Guillermo J.} and Alfred Nuttal and Nikiforos Kollias",
booktitle = "Photonic Therapeutics and Diagnostics XI",
note = "Photonic Therapeutics and Diagnostics XI ; Conference date: 07-02-2015 Through 08-02-2015",
}