Comparison of testing methods for detection of decreased linezolid susceptibility due to G2576T mutation of the 23S rRNA gene in Enterococcus faecium and Enterococcus faecalis

Chao Qi*, Xiaotian Zheng, Arlene Obias, Marc H. Scheetz, Michael Malczynski, John R. Warren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

E-test, Vitek 2, MicroScan, agar dilution, and disk diffusion were compared for detection of decreased linezolid susceptibility due to 23S rRNA gene G2576T mutation among 32 clinical Enterococcus strains initially reported as intermediate or resistant by E-test alone or Vitek 2 confirmed by E-test. Agar and broth dilution methods were in concordance with PCR detection of the mutation, and disk diffusion was somewhat less sensitive but equally specific.

Original languageEnglish (US)
Pages (from-to)1098-1100
Number of pages3
JournalJournal of clinical microbiology
Volume44
Issue number3
DOIs
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Microbiology (medical)

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