Comparison of the effects of succinylcholine and atracurium on intracranial pressure in monkeys with intracranial hypertension

John D. Haigh*, Edwin M. Nemoto, Andre M. DeWolf, Achiel L. Bleyaert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The effects of succinylcholine (1.5mg·kg-1 IV) administered five minutes after a defasciculating dose of curare (0.05 mg·kg-1 IV), were compared with the effects ofatracurium (0.5 mg·kg-1 IV) on intracranial pressure (ICP) in 13 cynomologus monkeys with intracranial hypertension (ICP· 25 mmHg). Neither succinylcholine nor atracurium increased ICP during general anaesthesia with 60 per cent N2O/O2, 0.5-1 per cent halothane. During a rapid sequence induction and intubation with thiopentone 5 mg·kg-1 IV, ICP increased equally with intubation following both atracurium (25 ± 1 to 32 ± 2 mmHg) and succinylcholine (25 ± 1 to 31 ± 2 mmHg) (p < 0.05). Intubation was also associated with significant increases in PaCO2, CVP and MAP. We conclude that in this primate model of intracranial hypertension, neither atracurium nor succinylcholine (when given following a defasciculating dose of curare) elevates ICP. In terms of the elevation of ICP associated with intubation, atracurium was found to offer no advantage over succinylcholine.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalCanadian Anaesthetists' Society Journal
Volume33
Issue number4
DOIs
StatePublished - Jul 1986

Keywords

  • brain: intracranial pressure, intracranial hypertension
  • neuromuscular relaxants: atracurium, succinylcholine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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