Comparison of the EORTC STO-22 and the FACT-Ga quality of life questionnaires for patients with gastric cancer

Aaron Woo, Terence Fu, Marko Popovic, Edward Chow*, David Cella, C. Shun Wong, Henry Lam, Natalie Pulenzas, Breanne Lechner, Sherlyn Vuong, Vithusha Ganesh, Andrew Bottomley

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


This review compares the development, characteristics, validity, and reliability of two well-known quality of life (QOL) assessment tools used in patients with gastric cancer: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Stomach (EORTC QLQ-STO22) and the Functional Assessment of Cancer Therapy-Gastric (FACT-Ga). A literature search was conducted using MEDLINE, EMBASE, and Cochrane CENTRAL (inception to April 2015) to identify studies that discussed the development, characteristics, validity and reliability of the EORTC QLQ-STO22 or the FACT-Ga. The QLQ-STO22 was developed with collaboration with patients, healthcare professionals and literature review and was mainly field tested in European countries. Conversely, items on the FACT-Ga were generated from interviews with patients and healthcare professionals concurrently in North America and Asia. While both modules involve a 7-day recall period and use Likert scales, the QLQ-STO22 and FACT-Ga differ in terms of QOL domain focus, quantity and presentation of items, response options, and scoring. However, both tools show good internal consistency, test-retest reliability, sensitivity to change and construct validity. In addition, both questionnaires have been internationally validated within a large sample of patients undergoing a variety of treatments, thus demonstrating their cross-cultural applicability. The EORTC QLQ-STO22 and FACT-Ga are both valid and reliable tools with unique strengths and weaknesses. Selection between instruments should consider specific patient characteristics and goals of the study.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalAnnals of Palliative Medicine
Issue number1
StatePublished - 2016


  • European organisation for research and treatment of cancer quality of life questionnaire-stomach (EORTC QLQ-STO22)
  • Functional assessment of cancer therapy-gastric (FACT-Ga)
  • Gastric cancer
  • Quality of life (QOL)
  • Questionnaire

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Advanced and Specialized Nursing


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