Comparison of the radioallergosorbent test and a quantitative solid-phase radioimmunoassay for the detection of ragweed-specific immunoglobulin E antibody in patients undergoing immunotherapy

C. Raymond Zeiss*, Leslie C. Grammer, Doris Levitz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Commercially available radioallergosorbent test (RAST) was compared with a quantitative solid-phase polystyrene tube radioimmunoassay (PTRIA) for the detection of ragweed-specific IgE antibody in sera of patients undergoing ragweed immunotherapy. Both assays showed good replication over a wide range of IgE antibody activity. The RAST was limited in the ability to discriminate between sera with high levels of specific IgE antibody. In addition, RAST gave falsely low values of IgE antibody activity in the presence of high levels of blocking antibody.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalThe Journal of allergy and clinical immunology
Volume67
Issue number2
DOIs
StatePublished - Feb 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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