Abstract
Commercially available radioallergosorbent test (RAST) was compared with a quantitative solid-phase polystyrene tube radioimmunoassay (PTRIA) for the detection of ragweed-specific IgE antibody in sera of patients undergoing ragweed immunotherapy. Both assays showed good replication over a wide range of IgE antibody activity. The RAST was limited in the ability to discriminate between sera with high levels of specific IgE antibody. In addition, RAST gave falsely low values of IgE antibody activity in the presence of high levels of blocking antibody.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-110 |
| Number of pages | 6 |
| Journal | The Journal of allergy and clinical immunology |
| Volume | 67 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1981 |
Funding
From the Section of Allergy-Immunology, Department of Medi-cine, Northwestern University Medical School. Supported by U.S. Public Health Service Grant Al 11403 and the Ernest S. Bazley Grant. Recetued for publication Aug. 19. 1980. Accepted for publication Oct. 13. 1980. Repr:nt requests 10: C. Raymond Zeiss, M.D., Northwestern Uni-ve+ty Medical School. 303 East Chicago Ave., Chicago, Il. 60611.
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology