Comparison of Thermal Burn-Induced and Excisional-Induced Scarring in Animal Models: A Review of the Literature

Adrian E. Rodrigues, David Dolivo, Yingxing Li, Thomas A. Mustoe, Robert Galiano, Seok Jong Hong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Significance: Scar formation is a natural result of mammalian wound healing. In humans and other mammals, however, deep dermal wounds and thermal injuries often result in formation of hypertrophic scars, leading to substantial morbidity and lending great importance to development of therapeutic modalities for burn scars. Clinical Issues: Thus, preclinical burn wound models that adequately simulate processes underlying human burn-induced wound healing, particularly those processes leading to chronic inflammation and development of hypertrophic scars, are critical to developing further treatment paradigms for clinical use. Approach: In this study, we review literature describing various burn models, focusing on their characteristics and the functional readouts that lead to generation of useful data. We also briefly discuss recent work using human ex vivo skin culture as an alternative to animal models, as well as our own development of rabbit ear wound models for burn scars, and assess the pros and cons of these models compared to other models. Future Direction: Understanding of the strengths and weaknesses of preclinical burn wound models will enable choice of the most appropriate wound model to answer particular clinically relevant questions, furthering research aimed at treating burn scars.

Original languageEnglish (US)
Pages (from-to)150-162
Number of pages13
JournalAdvances in Wound Care
Issue number3
StatePublished - Mar 2022


  • burn
  • excision
  • mouse
  • pig
  • rat
  • scar

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine


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