Comparison of two mathematical models for hyperthermic cell death

D. P. O'Neill, T. Peng, S. J. Payne

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Thermal treatments for tissue ablation rely upon the heating of cells past a threshold beyond which the cells are considered destroyed, denatured or killed. In this paper a theoretical, infinite state, lesion based model as proposed by Jung is modified to include a lesion healing process. An empirically based novel three-state model for cell death is proposed; and both models are fitted to experimental data of five different co-cultures of hepatocytes and lung fibroblasts with low RMS error. The models are compared and contrasted with regard to physiological relevance and ease of computational implementation. The suitability of substituting the infinite state model with a three state model is discussed and assessed with respect to multi-scale modeling.

Original languageEnglish (US)
Title of host publication6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages748-751
Number of pages4
Volume31 IFMBE
DOIs
StatePublished - Oct 22 2010
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
Duration: Aug 1 2010Aug 6 2010

Other

Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CountrySingapore
CitySingapore
Period8/1/108/6/10

Keywords

  • Cell death
  • hyperthermia
  • multi-scale

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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