TY - JOUR
T1 - Comparison of Zeiss cirrus and Optovue RTVue OCT angiography systems
T2 - A quantitative and qualitative approach examining the three capillary networks in diabetic retinopathy
AU - Chung, Christopher S.
AU - Nesper, Peter L.
AU - Park, Justin J.
AU - Fawzi, Amani A.
N1 - Funding Information:
Originally submitted November 16, 2017. Revision received March 22, 2018. Accepted for publication April 25, 2018. This work was funded in part by NIH DP3DK108248 (AAF), and research instrument support from Optovue (Fremont, California) and Zeiss Meditec (Dublin, California). The funders had no role in study design, data collection and analysis, data interpretation, decision to publish, or preparation of the manuscript. Mr. Nesper and Dr. Fawzi report grants from the NIH and non-financial support from Optovue and Zeiss Meditec during the conduct of the study. The remaining authors report no relevant financial disclosures. Address correspondence to Amani Fawzi, MD, Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611; email: afawzimd@gmail.com. doi: 10.3928/23258160-20181101-18
Publisher Copyright:
© Slack Incorporated. All rights reserved.
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND AND OBJECTIVES: Construct a method for visualizing the middle capillary plexus (MCP) using Zeiss optical coherence tomography angiography (OCTA) and compare to established segmentation methods using the Optovue system. PATIENTS AND METHODS: Twenty eyes with diabetic retinopathy were imaged. Visualization of the MCP, image artifacts, preservation of pathological changes, foveal avascular zone (FAZ) area, and vessel length density (VLD) were compared between devices. RESULTS: The authors successfully segmented the superficial (SCP), MCP, and deep (DCP) capillary plexuses on both devices. More images artifacts were detected on Optovue. Microaneurysms and telangiectatic vessels were better visualized in the MCP on the Optovue. FAZ area showed a strong correlation between the two instruments (r 2 = 0.666; P < .0001). The SCP had lower VLD compared to the MCP and DCP on both devices. CONCLUSION: The authors provide an objective and consistent method for manual segmentation using Zeiss OCTA to visualize the three retinal capillary plexuses.
AB - BACKGROUND AND OBJECTIVES: Construct a method for visualizing the middle capillary plexus (MCP) using Zeiss optical coherence tomography angiography (OCTA) and compare to established segmentation methods using the Optovue system. PATIENTS AND METHODS: Twenty eyes with diabetic retinopathy were imaged. Visualization of the MCP, image artifacts, preservation of pathological changes, foveal avascular zone (FAZ) area, and vessel length density (VLD) were compared between devices. RESULTS: The authors successfully segmented the superficial (SCP), MCP, and deep (DCP) capillary plexuses on both devices. More images artifacts were detected on Optovue. Microaneurysms and telangiectatic vessels were better visualized in the MCP on the Optovue. FAZ area showed a strong correlation between the two instruments (r 2 = 0.666; P < .0001). The SCP had lower VLD compared to the MCP and DCP on both devices. CONCLUSION: The authors provide an objective and consistent method for manual segmentation using Zeiss OCTA to visualize the three retinal capillary plexuses.
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U2 - 10.3928/23258160-20181101-18
DO - 10.3928/23258160-20181101-18
M3 - Article
C2 - 30457656
AN - SCOPUS:85056734470
VL - 49
SP - E198-E205
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 11
ER -