Comparisons between a new drug and active and placebo controls in an efficacy clinical trial

Charles W. Dunnett*, Ajit C. Tamhane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

D'Agostino and Heeren (DH) discussed the multiple comparison issues that arise in evaluating both sensitivity and efficacy in over‐the‐counter drug trials. We propose a general definition of sensitivity that includes DH's definition as a special case. We also propose a test for sensitivity that coincides with the MIN test of Laska and Meisner at one extreme but has the advantage of identifying specific drugs satisfying the sensitivity criterion when some fail to do so. We suggest that the test of Dunnett as well as an extension of it may be useful for the efficacy comparisons.

Original languageEnglish (US)
Pages (from-to)1057-1063
Number of pages7
JournalStatistics in Medicine
Volume11
Issue number8
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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