COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression

Nevan J. Krogan, Jim Dover, Shahram Khorrami, Jack F. Greenblatt, Jessica Schneider, Mark Johnston, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

294 Scopus citations

Abstract

The trithorax (Trx) family of proteins is required for maintaining a specific pattern of gene expression in some organisms. Recently we reported the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1 of the yeast Saccharomyces cerevisiae. Here we report that COMPASS catalyzes methylation of the fourth lysine of histone H3 in vitro. Set1 and several other components of COMPASS are also required for histone H3 methylation in vivo and for transcriptional silencing of a gene located near a chromosome telomere.

Original languageEnglish (US)
Pages (from-to)10753-10755
Number of pages3
JournalJournal of Biological Chemistry
Volume277
Issue number13
DOIs
StatePublished - Mar 29 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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