COMPASS and SWI/SNF complexes in development and disease

Bercin K. Cenik, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent studies are providing new insights into how two crucial families of the TrxG — the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF family of chromatin remodelling complexes — regulate gene expression and developmental programmes, and how misregulation of their activities through genetic abnormalities leads to pathologies such as developmental disorders and malignancies.

Original languageEnglish (US)
Pages (from-to)38-58
Number of pages21
JournalNature Reviews Genetics
Volume22
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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