Competitive inhibitors of human urokinase

H. Yang*, J. Henkin

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    The role of urokinase in matrix invasion and degradation by a variety of tumour cells, as well as in other invasive processes associated with both normal and pathological states has been well documented in recent years. Active site inhibitors of urokinase would provide a tool to assess the function of the enzyme in these processes. If urokinase proves to be a critical element, some of these inhibitors may also serve as lead compounds for potential therapeutic agents. Nevertheless, reports on small, synthetic, and competitive inhibitors of urokinase have been relatively few compared to inhibitors of other proteases. This paper reviews published work on competitive inhibitors of urokinase.

    Original languageEnglish (US)
    Pages (from-to)31-34
    Number of pages4
    JournalFibrinolysis and Proteolysis
    Volume6
    Issue numberSUPPL. 1
    DOIs
    StatePublished - Jan 1992

    ASJC Scopus subject areas

    • Hematology

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