Competitive inhibitors of human urokinase

H. Yang*, J. Henkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The role of urokinase in matrix invasion and degradation by a variety of tumour cells, as well as in other invasive processes associated with both normal and pathological states has been well documented in recent years. Active site inhibitors of urokinase would provide a tool to assess the function of the enzyme in these processes. If urokinase proves to be a critical element, some of these inhibitors may also serve as lead compounds for potential therapeutic agents. Nevertheless, reports on small, synthetic, and competitive inhibitors of urokinase have been relatively few compared to inhibitors of other proteases. This paper reviews published work on competitive inhibitors of urokinase.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalFibrinolysis and Proteolysis
Volume6
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Hematology

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