Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection

Jane E. Libbey; Matthew F. Cusick; Daniel J. Doty; Robert S. Fujinami

doi:10.1089/vim.2016.0175

Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection

Jane E. Libbey, Matthew F. Cusick, Daniel J. Doty, Robert S. Fujinami^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.

Original language	English (US)
Pages (from-to)	304-314
Number of pages	11
Journal	Viral Immunology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1089/vim.2016.0175
State	Published - Jun 2017
Externally published	Yes

Keywords

Theiler's murine encephalomyelitis virus
complement
innate immune response
picornavirus
seizures
viral encephalitis

ASJC Scopus subject areas

Molecular Medicine
Virology
Immunology

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10.1089/vim.2016.0175

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title = "Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection",

abstract = "The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.",

keywords = "Theiler's murine encephalomyelitis virus, complement, innate immune response, picornavirus, seizures, viral encephalitis",

author = "Libbey, {Jane E.} and Cusick, {Matthew F.} and Doty, {Daniel J.} and Fujinami, {Robert S.}",

note = "Publisher Copyright: {\textcopyright} 2017, Mary Ann Liebert, Inc.",

year = "2017",

month = jun,

doi = "10.1089/vim.2016.0175",

language = "English (US)",

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pages = "304--314",

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AU - Cusick, Matthew F.

AU - Doty, Daniel J.

AU - Fujinami, Robert S.

PY - 2017/6

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AB - The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.

KW - Theiler's murine encephalomyelitis virus

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KW - innate immune response

KW - picornavirus

KW - seizures

KW - viral encephalitis

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Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection

Abstract

Keywords

ASJC Scopus subject areas

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