Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection

Jane E. Libbey, Matthew F. Cusick, Daniel J. Doty, Robert S. Fujinami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.

Original languageEnglish (US)
Pages (from-to)304-314
Number of pages11
JournalViral Immunology
Volume30
Issue number5
DOIs
StatePublished - Jun 2017

Keywords

  • Theiler's murine encephalomyelitis virus
  • complement
  • innate immune response
  • picornavirus
  • seizures
  • viral encephalitis

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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