Complementary Approaches with Free-living and Parasitic Nematodes to Understanding Anthelmintic Resistance

Janneke Wit, Clayton M. Dilks, Erik C. Andersen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes of action of these drugs and mechanisms of resistance have predominantly come from studies of a related nonparasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemonchus contortus. Here, we discuss how our understanding of anthelmintic resistance and modes of action came from the interplay of results from each of these species. We argue that this 'cycle of discovery', where results from one species inform the design of experiments in the other, can use the complementary strengths of both to understand anthelmintic modes of action and mechanisms of resistance.

Original languageEnglish (US)
Pages (from-to)240-250
Number of pages11
JournalTrends in Parasitology
Volume37
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • C. elegans
  • anthelmintics
  • drug resistance
  • natural diversity

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Complementary Approaches with Free-living and Parasitic Nematodes to Understanding Anthelmintic Resistance'. Together they form a unique fingerprint.

Cite this