Complete cDNA sequence of rat atrial myosin light chain 1: Patterns of expression during development and with hypertension

Arthur S. Rovner, Elizabeth M. McNally, Leslie A. Leinwand*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Distinct atrial and ventricular isoforms of myosin light chain 1 (LC1) exist in mammals. The atrial LC1 is also expressed in fetal ventricular and skeletal muscle. Here we present a full length cDNA encoding a rat atrial LC1, based upon homology with previously reported LC1 sequences and its atrial-specific pattern of RNA hybridization in adult cardiac muscle. Atrial and ventricular RNA expression were studied during rat development and with chronic hypertension. Atrial LC1 mRNA was expressed in rat atria throughout development, and was coexpressed in rat atria througout development, and was coexpressed with ventricular LC1 mRNA inthe hearts of 12-day and 16-day embryos, and in the ventricles of newborn rats (<24 hours). In 9-day-old neonates, atrial LC1 mRNA expression was restricted to rat atrium. In adult rats exhibiting renovascular hypertension, the expression of the atrial and ventricular LC1 mRNAs was unchanged from that seen in normal control animals.

Original languageEnglish (US)
Pages (from-to)1581-1586
Number of pages6
JournalNucleic acids research
Volume18
Issue number6
StatePublished - 1990

ASJC Scopus subject areas

  • Genetics

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