Complete genome sequence of klebsiella pneumoniae strain TK421, a conjugative hypervirulent isolate

Travis J. Kochan; Egon A. Ozer; Nathan B. Pincus; Margaret A. Fitzpatrick; Alan R. Hauser

doi:10.1128/MRA.01408-19

Complete genome sequence of klebsiella pneumoniae strain TK421, a conjugative hypervirulent isolate

Travis J. Kochan^*, Egon A. Ozer, Nathan B. Pincus, Margaret A. Fitzpatrick, Alan R. Hauser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Klebsiella pneumoniae is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant K. pneumoniae strains.

Original language	English (US)
Article number	e01408-19
Journal	Microbiology Resource Announcements
Volume	9
Issue number	3
DOIs	https://doi.org/10.1128/MRA.01408-19
State	Published - Jan 16 2020

ASJC Scopus subject areas

Immunology and Microbiology (miscellaneous)
Genetics
Molecular Biology

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abstract = "Klebsiella pneumoniae is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant K. pneumoniae strains.",

author = "Kochan, {Travis J.} and Ozer, {Egon A.} and Pincus, {Nathan B.} and Fitzpatrick, {Margaret A.} and Hauser, {Alan R.}",

note = "Funding Information: T.J.K. was supported by NIAID grant T32 AI007476. N.B.P. was supported in part by NIGMS grants T32 GM008061 and T32 GM008152. A.R.H. was supported by NIAID grants RO1 AI118257, U19 AI135964, K24 AI04831, and R21 AI129167. E.A.O. was supported by NIAID grant U19 AI135964. Publisher Copyright: {\textcopyright} 2020 Kochan et al.",

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AU - Ozer, Egon A.

AU - Pincus, Nathan B.

AU - Fitzpatrick, Margaret A.

AU - Hauser, Alan R.

N1 - Funding Information: T.J.K. was supported by NIAID grant T32 AI007476. N.B.P. was supported in part by NIGMS grants T32 GM008061 and T32 GM008152. A.R.H. was supported by NIAID grants RO1 AI118257, U19 AI135964, K24 AI04831, and R21 AI129167. E.A.O. was supported by NIAID grant U19 AI135964. Publisher Copyright: © 2020 Kochan et al.

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N2 - Klebsiella pneumoniae is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant K. pneumoniae strains.

AB - Klebsiella pneumoniae is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant K. pneumoniae strains.

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Complete genome sequence of klebsiella pneumoniae strain TK421, a conjugative hypervirulent isolate

Abstract

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