Complete hydatidiform mole and coexisting normal fetuses: A report of two cases with contrasting outcomes

Shohreh Shahabi; Geneviève Naome; Laurence Cobin; Anne Verougstraete; Louise Masters; Virginie Zengbe; Jean Christophe Noël; Efraim Freddy Avni; Catherine Donner; Alain Verhest; Walter Foulon; Frédéric Rodesch

Complete hydatidiform mole and coexisting normal fetuses: A report of two cases with contrasting outcomes

Shohreh Shahabi^*, Geneviève Naome, Laurence Cobin, Anne Verougstraete, Louise Masters, Virginie Zengbe, Jean Christophe Noël, Efraim Freddy Avni, Catherine Donner, Alain Verhest, Walter Foulon, Frédéric Rodesch

^*Corresponding author for this work

Medical Social Sciences

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17 Scopus citations

Abstract

BACKGROUND: Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation induction agents. CASES: We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. CONCLUSION: The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.

Original language	English (US)
Pages (from-to)	756-760
Number of pages	5
Journal	Journal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume	42
Issue number	11
State	Published - Nov 1997

Keywords

Hydatidiform mole
Pregnancy, multiple
Twins

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Cite this

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title = "Complete hydatidiform mole and coexisting normal fetuses: A report of two cases with contrasting outcomes",

abstract = "BACKGROUND: Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation induction agents. CASES: We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. CONCLUSION: The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.",

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AU - Shahabi, Shohreh

AU - Naome, Geneviève

AU - Cobin, Laurence

AU - Verougstraete, Anne

AU - Masters, Louise

AU - Zengbe, Virginie

AU - Noël, Jean Christophe

AU - Avni, Efraim Freddy

AU - Donner, Catherine

AU - Verhest, Alain

AU - Foulon, Walter

AU - Rodesch, Frédéric

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N2 - BACKGROUND: Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation induction agents. CASES: We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. CONCLUSION: The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.

AB - BACKGROUND: Multiple pregnancies consisting of a complete hydatidiform mole and coexisting fetuses are relatively rare but may become more common due to the increasing use of ovulation induction agents. CASES: We report on a twin and a triplet pregnancy, conceived using clomiphene citrate, with contrasting outcomes. The twin pregnancy resulted in a term delivery of a healthy singleton and the triplet pregnancy in a termination at 17 weeks followed by the development of choriocarcinoma. CONCLUSION: The few cases available suggest that a subgroup of complete moles follows a more benign course and can be managed conservatively, allowing the pregnancy to go to term with appropriate follow-up, whereas other cases follow a more aggressive course. Larger case series are needed to develop definitive protocols.

KW - Hydatidiform mole

KW - Pregnancy, multiple

KW - Twins

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Complete hydatidiform mole and coexisting normal fetuses: A report of two cases with contrasting outcomes

Abstract

Keywords

ASJC Scopus subject areas

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