Complete Resolution of Pure Red Cell Aplasia in a Patient With Chronic Lymphocytic Leukemia Following Antithymocyte Globulin Therapy

Cynthia A. Radosevich, Leo I. Gordon, Susan C. Weil, Robert J. Marder, Steven T. Rosen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Pure red cell aplasia has been reported to be associated with chronic lymphocytic leukemia. It has been proposed that this complication may be a result of T-cell populations that suppress erythropoiesis. It has been postulated that antithymocyte globulin might reverse this abnormality by eliminating the population of suppressor T cells responsible for this inhibition. We treated a 74-year-old man who had B-cell chronic lymphocytic leukemia and pure red cell aplasia that was refractory to cytotoxic and corticosteroid therapy with equine antithymocyte globulin and methylprednisolone sodium succinate. This therapy resulted in a durable complete remission of both the chronic lymphocytic leukemia and the pure red cell aplasia and was associated with normalization of helper/suppressor T-cell ratios in the bone marrow. Antithymocyte globulin should be investigated further as a therapeutic modality for patients with pure red cell aplasia associated with chronic lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)723-725
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume259
Issue number5
DOIs
StatePublished - Feb 5 1988

ASJC Scopus subject areas

  • Medicine(all)

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