Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open-label, single-arm feasibility study in diabetic foot ulcers

David G. Armstrong, Dennis P. Orgill, Robert Galiano, Paul M. Glat, Marissa Carter, Charles M. Zelen*, William W. Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by leveraging the endogenous repair capabilities of the patient's healthy skin. The AHSC's ability to close DFUs with a single treatment was evaluated in an open-label, single-arm feasibility study. Eleven patients with DFUs extending up to tendon, bone, or capsule received a single topical application of AHSC. Closure was documented weekly with high-resolution digital photography and wound planimetry. All 11 DFUs demonstrated successful graft take. Ten DFUs closed within 8 weeks. The median time-to-complete closure was 25 days. The mean percent area reduction for all 11 wounds at 4 weeks was 83%. There were no adverse events related to the AHSC treatment site. This pilot study demonstrated AHSC may be a viable single application topical intervention for DFUs and warrants investigation in larger, controlled studies.

Original languageEnglish (US)
Pages (from-to)1366-1375
Number of pages10
JournalInternational Wound Journal
Volume17
Issue number5
DOIs
StatePublished - Oct 1 2020

Keywords

  • autologous homologous skin construct
  • diabetic foot ulcer
  • novel therapy
  • wound healing

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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