Complex 3D microfluidic architectures formed by mechanically guided compressive buckling

Haiwen Luan, Qihui Zhang, Tzu Li Liu, Xueju Wang, Shiwei Zhao, Heling Wang, Shenglian Yao, Yeguang Xue, Jean Won Kwak, Wubin Bai, Yameng Xu, Mengdi Han, Kan Li, Zhengwei Li, Xinchen Ni, Jilong Ye, Dongwhi Choi, Quansan Yang, Jae Hwan Kim, Shuo LiShulin Chen, Changsheng Wu, Di Lu, Jan Kai Chang, Zhaoqian Xie, Yonggang Huang*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Microfluidic technologies have wide-ranging applications in chemical analysis systems, drug delivery platforms, and artificial vascular networks. This latter area is particularly relevant to 3D cell cultures, engineered tissues, and artificial organs, where volumetric capabilities in fluid distribution are essential. Existing schemes for fabricating 3D microfluidic structures are constrained in realizing desired layout designs, producing physiologically relevant microvascular structures, and/or integrating active electronic/optoelectronic/microelectromechanical components for sensing and actuation. This paper presents a guided assembly approach that bypasses these limitations to yield complex 3D microvascular structures from 2D precursors that exploit the full sophistication of 2D fabrication methods. The capabilities extend to feature sizes <5 μm, in extended arrays and with various embedded sensors and actuators, across wide ranges of overall dimensions, in a parallel, high-throughput process. Examples include 3D microvascular networks with sophisticated layouts, deterministically designed and constructed to expand the geometries and operating features of artificial vascular networks.

Original languageEnglish (US)
Article numbereabj3686
JournalScience Advances
Volume7
Issue number43
DOIs
StatePublished - Oct 2021

ASJC Scopus subject areas

  • General

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