Complex carbohydrate intolerance: Diagnostic pitfaiis and approach to management

John D. Lloyd-Still*, Robert Listernick, Gloria Buentello

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Complex carbohydrate intolerance occurred in three of 105 patients with protracted diarrhea of infancy. Nosocomial gastroenteritis complicated a primary disorder of carbohydrate absorption (primary glucose galactose malabsorption, two; primary sucrase isomaltase deficiency, one) in all patients. Their course was characterized by protracted diarrhea, variable degrees of villus atrophy on intestinal biopsy tissue, and negative caloric balance requiring intravenous alimentation for periods varying from 6 to 16 weeks. Dietary management required rigid exclusion of all offending carbohydrates from the diet. Delay in the diagnosis of primary carbohydrate intolerance varied from 2 weeks to 6 months. Complex carbohydrate intolerance may be more common than has been reported, and should be considered in all infants with protracted diarrhea of infancy when there is persistent carbohydrate intolerance.

Original languageEnglish (US)
Pages (from-to)709-713
Number of pages5
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1988

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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